Study on the degradation characteristics and pathway of torasemide in water via electron beam irradiation

Zhibo ZHANG; Haiyang SHAO; Lei CHEN; Chengkai MAO; Yingfei REN; Gang XU

doi:10.11889/j.1000-3436.2022-0042

Journal of Radiation Research and Radiation Processing, Volume. 40, Issue 5, 050201(2022)

Study on the degradation characteristics and pathway of torasemide in water via electron beam irradiation

Zhibo ZHANG, Haiyang SHAO^*, Lei CHEN, Chengkai MAO, Yingfei REN, and Gang XU

Author Affiliations

School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China

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Figures & Tables(8)

Fig. 1. Degradation of torasemide as a function of absorbed dose at different initial concentrations

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Fig. 2. Degradation of torasemide with various radical scavengers

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Fig. 3. Effect of solution pH on torasemide degradation by electron beam irradiation

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Fig. 4. Effect of H₂O₂on torasemide degradation by electron beam irradiation

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Fig. 5. Effects of $C O_{3}^{2 -} (a)$ , $N O_{2}^{-} (b), S O_{3}^{2 -} (c), a n d S O_{4}^{2 -} (d)$ on torasemide degradation by electron beam irradiation

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Fig. 6. Proposed pathways of torasemide degradation during EB irradiation

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Table 1. The dose constant k_d, D_0.5, D_0.9 and the correlation coefficients R² at different initial concentrations of torasemide

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Table 1. The dose constant k_d, D_0.5, D_0.9 and the correlation coefficients R² at different initial concentrations of torasemide

初始浓度 / (μmol⋅L^-1)	k_d / kGy^-1	D_0.5所需剂量 / kGy	D_0.9所需剂量 / kGy	R²
Initial concentration	Dose constant	Doses required to D_0.5	Doses required to D_0.9
100	4.239	0.164	0.543	0.999 8
150	2.744	0.253	0.839	1.000 0
250	1.466	0.473	1.571	0.997 4
300	1.220	0.568	1.887	0.998 9

Table 2. Torasemide and its main transformation products of produced during EB irradiation.

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Table 2. Torasemide and its main transformation products of produced during EB irradiation.

转化产物 Transformation products	分子式 Molecular formula	质荷比 Exact monoisotopic mass of [M+H]⁺	保留时间 / min Retention time	误差 / (mg∙L^-1) Mass error
托拉塞米 Torasemide	C₁₆H₂₀N₄O₃S	349.132 9	9.83	0.3
TP102	C₄H₁₀N₂O	103.086 6	3.55	1.1
TP173	C₅H₇N₃O₂S	174.032 2	2.97	1.3
TP258	C₉H₁₄N₄O₃S	259.085 9	3.11	0.2
TP263	C₁₂H₁₃N₃O₂S	264.080 1	4.45	1.8
TP279	C₁₂H₁₃N₃O₃S	280.075 0	4.98	1.3
TP306	C₁₃H₁₄N₄O₃S	307.085 9	4.46	1.5
TP322	C₁₃H₁₄N₄O₄S	323.080 9	3.68	2.0
TP362	C₁₆H₁₈N₄O₄S	363.112 2	5.30	3.4
TP364	C₁₆H₂₀N₄O₄S	365.127 8	5.30	-4.4

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Zhibo ZHANG, Haiyang SHAO, Lei CHEN, Chengkai MAO, Yingfei REN, Gang XU. Study on the degradation characteristics and pathway of torasemide in water via electron beam irradiation[J]. Journal of Radiation Research and Radiation Processing, 2022, 40(5): 050201

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Paper Information

Category: Research Articles

Received: Feb. 19, 2022

Accepted: Jun. 28, 2022

Published Online: Nov. 3, 2022

The Author Email: SHAO Haiyang (shy2018@shu.edu.cn)

DOI:10.11889/j.1000-3436.2022-0042

Topics

laser devices and laser physics

Lasers and Laser Optics

Laser physics

laser manufacturing

Instrumentation, Measurement and Metrology

Table 1. The dose constant kd, D0.5, D0.9 and the correlation coefficients R2 at different initial concentrations of torasemide

Table 1. The dose constant kd, D0.5, D0.9 and the correlation coefficients R2 at different initial concentrations of torasemide

Table 2. Torasemide and its main transformation products of produced during EB irradiation.

Table 2. Torasemide and its main transformation products of produced during EB irradiation.

Table 1. The dose constant k_d, D_0.5, D_0.9 and the correlation coefficients R² at different initial concentrations of torasemide

Table 1. The dose constant k_d, D_0.5, D_0.9 and the correlation coefficients R² at different initial concentrations of torasemide