Journal of Radiation Research and Radiation Processing, Volume. 41, Issue 2, 020101(2023)
Radiobiology and treatment plan progress of FLASH radiotherapy
[1] V Favaudon, L Caplier, V Monceau et al. Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice. Science Translational Medicine, 6, 245ra293(2014).
[2] H Kacem, A Almeida, N Cherbuin et al. Understanding the FLASH effect to unravel the potential of ultra-high dose rate irradiation. International Journal of Radiation Biology, 98, 506-516(2022).
[3] E Schüler, M Acharya, P Montay-Gruel et al. Ultra-high dose rate electron beams and the FLASH effect: from preclinical evidence to a new radiotherapy paradigm. Medical Physics, 49, 2082-2095(2022).
[4] W Tinganelli, U Weber, A Puspitasari et al. FLASH with carbon ions: Tumor control, normal tissue sparing, and distal metastasis in a mouse osteosarcoma model. Radiotherapy and Oncology, 175, 185-190(2022).
[5] M C Vozenin, P De Fornel, K Petersson et al. The advantage of FLASH radiotherapy confirmed in mini-pig and cat-cancer patients. Clinical Cancer Research, 25, 35-42(2019).
[6] E Konradsson, M L Arendt, K Bastholm Jensen et al. Establishment and initial experience of clinical FLASH radiotherapy in canine cancer patients. Frontiers in Oncology, 11, 658004(2021).
[7] J Bourhis, W J Sozzi, P G Jorge et al. Treatment of a first patient with FLASH-radiotherapy. Radiotherapy and Oncology, 139, 18-22(2019).
[8] R J Berry, E J Hall, D W Forster et al. Survival of mammalian cells exposed to x rays at ultra-high dose-rates. The British Journal of Radiology, 42, 102-107(1969).
[9] T L Phillips, B R Worsnop. Ultra-high dose-rate effects in radiosensitive bacteria. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 14, 573-575(1969).
[10] E R Epp, H Weiss, A Santomasso. The oxygen effect in bacterial cells irradiated with high-intensity pulsed electrons. Radiation Research, 34, 320-325(1968).
[11] A M Zakaria, N W Colangelo, J Meesungnoen et al. Transient hypoxia in water irradiated by swift carbon ions at ultra-high dose rates: implication for FLASH carbon-ion therapy. Canadian Journal of Chemistry, 99, 842-849(2021).
[12] X Cao, R X Zhang, T V Esipova et al. Quantification of oxygen depletion during FLASH irradiation in vitro and in vivo. International Journal of Radiation Oncology, Biology, Physics, 111, 240-248(2021).
[13] J Jansen, J Knoll, E Beyreuther et al. Does FLASH deplete oxygen? Experimental evaluation for photons, protons, and carbon ions. Medical Physics, 48, 3982-3990(2021).
[14] Y F Lai, X Jia, Y J Chi. Modeling the effect of oxygen on the chemical stage of water radiolysis using GPU-based microscopic Monte Carlo simulations, with an application in FLASH radiotherapy. Physics in Medicine and Biology, 66, 025004(2021).
[15] B C Rothwell, N F Kirkby, M J Merchant et al. Determining the parameter space for effective oxygen depletion for FLASH radiation therapy. Physics in Medicine and Biology, 66, 055020(2021).
[16] C M Okoro, E Schüler, C M Taniguchi. The therapeutic potential of FLASH-RT for pancreatic cancer. Cancers, 14, 1167(2022).
[17] D Boscolo, E Scifoni, M Durante et al. May oxygen depletion explain the FLASH effect? A chemical track structure analysis. Radiotherapy and Oncology, 162, 68-75(2021).
[18] J D Wilson, E M Hammond, G S Higgins et al. Ultra-high dose rate (FLASH) radiotherapy: silver bullet or fool's gold?. Frontiers in Oncology, 9, 1563(2020).
[19] K Petersson, G Adrian, K Butterworth et al. A quantitative analysis of the role of oxygen tension in FLASH radiation therapy. International Journal of Radiation Oncology, Biology, Physics, 107, 539-547(2020).
[20] M C Vozenin, J H Hendry, C L Limoli. Biological benefits of ultra-high dose rate FLASH radiotherapy: sleeping beauty awoken. Clinical Oncology, 31, 407-415(2019).
[21] A K Hu, R Qiu, Z Wu et al. A computational model for oxygen depletion hypothesis in FLASH effect. Radiation Research, 197, 175-183(2022).
[22] S Hornsey, D K Bewley. Hypoxia in mouse intestine induced by electron irradiation at high dose-rates. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 19, 479-483(1971).
[23] D R Spitz, G R Buettner, M S Petronek et al. An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses. Radiotherapy and Oncology, 139, 23-27(2019).
[24] P Wardman. Radiotherapy using high-intensity pulsed radiation beams (FLASH): a radiation-chemical perspective. Radiation Research, 194, 607-617(2020).
[25] A A Friedl, K M Prise, K T Butterworth et al. Radiobiology of the FLASH effect. Medical Physics, 49, 1993-2013(2022).
[26] R Labarbe, L Hotoiu, J Barbier et al. A physicochemical model of reaction kinetics supports peroxyl radical recombination as the main determinant of the FLASH effect. Radiotherapy and Oncology, 153, 303-310(2020).
[27] H Y Zhu, D H Xie, Y W Yang et al. Radioprotective effect of X-ray abdominal FLASH irradiation: adaptation to oxidative damage and inflammatory response may be benefiting factors. Medical Physics, 49, 4812-4822(2022).
[28] V Favaudon, R Labarbe, C L Limoli. Model studies of the role of oxygen in the FLASH effect. Medical Physics, 49, 2068-2081(2022).
[29] G Blain, J Vandenborre, D Villoing et al. Proton irradiations at ultra-high dose rate vs. conventional dose rate: strong impact on hydrogen peroxide yield. Radiation Research, 198, 318-324(2022).
[30] A K Hu, R Qiu, Z Wu et al. CPU-GPU coupling independent reaction times method in NASIC and application in water radiolysis by FLASH irradiation. Biomedical Physics & Engineering Express, 8, 025015(2022).
[31] Y E Kim, S H Gwak, B J Hong et al. Effects of ultra-high doserate FLASH irradiation on the tumor microenvironment in lewis lung carcinoma: role of myosin light chain. International Journal of Radiation Oncology, Biology, Physics, 109, 1440-1453(2021).
[32] T Prempree, A Michelsen, T Merz. The repair time of chromosome breaks induced by pulsed X-rays on ultra-high dose-rate. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 15, 571-574(1969).
[33] H B Michaels, E R Epp, C C Ling et al. Oxygen sensitization of CHO cells at ultrahigh dose rates: prelude to oxygen diffusion studies. Radiation Research, 76, 510-521(1978).
[34] R J Schulz, R Nath, J R Testa. The effects of ultra-high dose rates on survival and sublethal repair in Chinese-hamster cells. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 33, 81-88(1978).
[35] D Ohsawa, Y Hiroyama, A Kobayashi et al. DNA strand break induction of aqueous plasmid DNA exposed to 30 MeV protons at ultra-high dose rate. Journal of Radiation Research, 63, 255-260(2022).
[36] A Perstin, Y Poirier, A Sawant et al. Quantifying the DNA-damaging effects of FLASH irradiation with plasmid DNA. International Journal of Radiation Oncology, Biology, Physics, 113, 437-447(2022).
[37] C Fouillade, S Curras-Alonso, L Giuranno et al. FLASH irradiation spares lung progenitor cells and limits the incidence of radio-induced senescence. Clinical Cancer Research, 26, 1497-1506(2020).
[38] G Adrian, E Konradsson, S Beyer et al. Cancer cells can exhibit a sparing FLASH effect at low doses under normoxic in vitro- conditions. Frontiers in Oncology, 11, 686142(2021).
[39] X L Shi, Y W Yang, W Zhang et al. FLASH X-ray spares intestinal crypts from pyroptosis initiated by cGAS-STING activation upon radioimmunotherapy. Proceedings of the National Academy of Sciences of the United States of America, 119, e2208506119(2022).
[40] M Buonanno, V Grilj, D J Brenner. Biological effects in normal cells exposed to FLASH dose rate protons. Radiotherapy and Oncology, 139, 51-55(2019).
[41] C R Cooper, D Jones, G D Jones et al. FLASH irradiation induces lower levels of DNA damage ex vivo, an effect modulated by oxygen tension, dose, and dose rate. The British Journal of Radiology, 95, 20211150(2022).
[42] J Y Jin, A Gu, W Wang et al. Ultra-high dose rate effect on circulating immune cells: a potential mechanism for FLASH effect?. Radiotherapy and Oncology, 149, 55-62(2020).
[43] J T Eggold, S Chow, S Melemenidis et al. Abdominopelvic FLASH irradiation improves PD-1 immune checkpoint inhibition in preclinical models of ovarian cancer. Molecular Cancer Therapeutics, 21, 371-381(2022).
[44] P Montay-Gruel, M Markarian, B D Allen et al. Ultra-high-dose-rate FLASH irradiation limits reactive gliosis in the brain. Radiation Research, 194, 636-645(2020).
[45] S Cunningham, S McCauley, K Vairamani et al. FLASH proton pencil beam scanning irradiation minimizes radiation-induced leg contracture and skin toxicity in mice. Cancers, 13, 1012(2021).
[46] A Velalopoulou, I V Karagounis, G M Cramer et al. FLASH proton radiotherapy spares normal epithelial and mesenchymal tissues while preserving sarcoma response. Cancer Research, 81, 4808-4821(2021).
[47] M Schwarz, E Traneus, S Safai et al. Treatment planning for Flash radiotherapy: general aspects and applications to proton beams. Medical Physics, 49, 2861-2874(2022).
[48] N Esplen, M S Mendonca, M Bazalova-Carter. Physics and biology of ultrahigh dose-rate (FLASH) radiotherapy: a topical review. Physics in Medicine and Biology, 65, 23TR03(2020).
[49] Yingzi ZHANG, Shengyu YAO, Jiayi CHEN et al. Hot spot analysis on FLASH radiotherapy technology. Journal of Radiation Research and Radiation Processing, 38, 060103(2020).
[50] W Tinganelli, O Sokol, M Quartieri et al. Ultra-high dose rate (FLASH) carbon ion irradiation: dosimetry and first cell experiments. International Journal of Radiation Oncology, Biology, Physics, 112, 1012-1022(2022).
[51] M Tashiro, Y Yoshida, T Oike et al. First human cell experiments with FLASH carbon ions. Anticancer Research, 42, 2469-2477(2022).
[52] W Zou, E S Diffenderfer, K A Cengel et al. Current delivery limitations of proton PBS for FLASH. Radiotherapy and Oncology, 155, 212-218(2021).
[53] J Farr, V Grilj, V Malka et al. Ultra-high dose rate radiation production and delivery systems intended for FLASH. Medical Physics, 49, 4875-4911(2022).
[54] P van Marlen, M Dahele, M Folkerts et al. Bringing FLASH to the clinic: treatment planning considerations for ultrahigh dose-rate proton beams. International Journal of Radiation Oncology, Biology, Physics, 106, 621-629(2020).
[55] M L Kang, S Y Wei, J Isabelle Choi et al. Quantitative assessment of 3D dose rate for proton pencil beam scanning FLASH radiotherapy and its application for lung hypofractionation treatment planning. Cancers, 13, 3549(2021).
[56] S van de Water, S Safai, J M Schippers et al. Towards FLASH proton therapy: the impact of treatment planning and machine characteristics on achievable dose rates. Acta Oncologica, 58, 1463-1469(2019).
[57] M Krieger, S van de Water, M M Folkerts et al. A quantitative FLASH effectiveness model to reveal potentials and pitfalls of high dose rate proton therapy. Medical Physics, 49, 2026-2038(2022).
[58] P van Marlen, M Dahele, M Folkerts et al. Ultra-high dose rate transmission beam proton therapy for conventionally fractionated head and neck cancer: treatment planning and dose rate distributions. Cancers, 13, 1859(2021).
[59] S Y Wei, H B Lin, J Isabelle Choi et al. FLASH radiotherapy using single-energy proton PBS transmission beams for hypofractionation liver cancer: dose and dose rate quantification. Frontiers in Oncology, 11, 813063(2022).
[60] S Y Wei, H B Lin, J Isabelle Choi et al. A novel proton pencil beam scanning FLASH RT delivery method enables optimal OAR sparing and ultra-high dose rate delivery: a comprehensive dosimetry study for lung tumors. Cancers, 13, 5790(2021).
[61] H Gao, J L Liu, Y T Lin et al. Simultaneous dose and dose rate optimization (SDDRO) of the FLASH effect for pencil-beam-scanning proton therapy. Medical Physics, 49, 2014-2025(2022).
[62] P van Marlen, W Verbakel, B J Slotman et al. Single-fraction 34 Gy lung stereotactic body radiation therapy using proton transmission beams: FLASH-dose calculations and the influence of different dose-rate methods and dose/dose-rate thresholds. Advances in Radiation Oncology, 7, 100954(2022).
Get Citation
Copy Citation Text
Xun WU, Ruifeng LIU, Qiuning ZHANG, Xiaohu WANG. Radiobiology and treatment plan progress of FLASH radiotherapy[J]. Journal of Radiation Research and Radiation Processing, 2023, 41(2): 020101
Category: Research Articles
Received: Nov. 2, 2022
Accepted: Feb. 13, 2023
Published Online: Jul. 24, 2023
The Author Email: WANG Xiaohu (xhwang@impcas.ac.cn)