[1] I Vercellino, L A Sazanov. The assembly, regulation and function of the mitochondrial respiratory chain. Nature Reviews Molecular Cell Biology, 23, 141-161(2022).

[2] P Monian, X Jiang. Clearing the final hurdles to mitochondrial apoptosis: regulation post cytochrome C release. Experimental Oncology, 34, 185-191(2012).

[3] A Légiot, C Céré, T Dupoiron et al. Mitochondria-Associated Membranes (MAMs) are involved in Bax mitochondrial localization and cytochrome c release. Microbial Cell, 6, 257-266(2019).

[4] A V Kulikov, E S Shilov, I A Mufazalov et al. Cytochrome c: the Achilles’ heel in apoptosis. Cellular and Molecular Life Sciences, 69, 1787-1797(2012).

[5] P U Emeagi, S Van Lint, C Goyvaerts et al. Proinflammatory characteristics of SMAC/DIABLO-induced cell death in antitumor therapy. Cancer Research, 72, 1342-1352(2012).

[6] M Z Zhang, J Zheng, R Nussinov et al. Release of cytochrome C from bax pores at the mitochondrial membrane. Scientific Reports, 7, 2635(2017).

[7] J A Grosser, M E Maes, R W Nickells. Characteristics of intracellular propagation of mitochondrial BAX recruitment during apoptosis. Apoptosis, 26, 132-145(2021).

[8] Y H Qiu, T S Zhang, X W Wang et al. Mitochondria autophagy: a potential target for cancer therapy. Journal of Drug Targeting, 29, 576-591(2021).

[9] M Vara-Perez, B Felipe-Abrio, P Agostinis. Mitophagy in cancer: a tale of adaptation. Cells, 8, 493(2019).

[10] E Villa, E Proïcs, C Rubio-Patiño et al. Parkin-independent mitophagy controls chemotherapeutic response in cancer cells. Cell Reports, 20, 2846-2859(2017).

[11] L Yu, X S Yang, X Li et al. Pink1/PARK2/mROS-dependent mitophagy initiates the sensitization of cancer cells to radiation. Oxidative Medicine and Cellular Longevity, 5595652(2021).

[12] F Le Guerroué, F Eck, J Jung et al. Autophagosomal content profiling reveals an LC3C-dependent piecemeal mitophagy pathway. Molecular Cell, 68, 786-796.e6(2017).

[13] W Tinganelli, M Durante. Carbon ion radiobiology. Cancers, 12, 3022(2020).

[14] M Durante, J Debus, J S Loeffler. Physics and biomedical challenges of cancer therapy with accelerated heavy ions. Nature Reviews Physics, 3, 777-790(2021).

[15] Y Li, X M Li, J C Yang et al. Flourish of proton and carbon ion radiotherapy in China. Frontiers in Oncology, 12, 819905(2022).

[16] G L Jiang. Particle therapy for cancers: a new weapon in radiation therapy. Frontiers of Medicine, 6, 165-172(2012).

[17] T Kamada, H Tsujii, E A Blakely et al. Carbon ion radiotherapy in Japan: an assessment of 20 years of clinical experience. The Lancet Oncology, 16, e93-e100(2015).

[18] M Karube, N Yamamoto, Y Shioyama et al. Carbon-ion radiotherapy for patients with advanced stage non-small-cell lung cancer at multicenters. Journal of Radiation Research, 58, 761-764(2017).

[19] J S Wang, H J Wang, H L Qian. Biological effects of radiation on cancer cells. Military Medical Research, 5, 20(2018).

[20] D Averbeck, C Rodriguez-Lafrasse. Role of mitochondria in radiation responses: epigenetic, metabolic, and signaling impacts. International Journal of Molecular Sciences, 22, 11047(2021).

[21] M Durante. New challenges in high-energy particle radiobiology. British Journal of Radiology, 87, 20130626(2014).

[22] Guozhen CAO, Dong LU, Miaomiao ZHANG et al. Effects on mitochondrial transmembrane potential of Saccharomyces cerevisiae by X-ray irradiation. Journal of Radiation Research and Radiation Processing, 33, 010201(2015).

[23] Chao GU, Jihua NIE, Zhihai CHEN et al. Changes of malignant transforming mitochondria in human bronchial epithelial cells induced by α-particle radiation. Journal of Radiation Research and Radiation Processing, 31, 37-41(2013).

[24] J Liermann, P Naumann, F Weykamp et al. Effectiveness of carbon ion radiation in locally advanced pancreatic cancer. Frontiers in Oncology, 11, 708884(2021).

[25] Y Q Wang, Y Nartiss, B Steipe et al. ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy. Autophagy, 8, 1462-1476(2012).

[26] M P M Soutar, L Kempthorne, E Annuario et al. FBS/BSA media concentration determines CCCP’s ability to depolarize mitochondria and activate PINK1-PRKN mitophagy. Autophagy, 15, 2002-2011(2019).

[27] S Q Liang, G M Zhou, W T Hu. Research progress of heavy ion radiotherapy for non-small-cell lung cancer. International Journal of Molecular Sciences, 23, 2316(2022).

[28] H G Ruan, J Xiong. Value of carbon-ion radiotherapy for early stage non-small cell lung cancer. Clinical and Translational Radiation Oncology, 36, 16-23(2022).

[29] A Tomiyama, K Tachibana, K Suzuki et al. MEK-ERK-dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death. Cell Death & Disease, 1, e60(2010).

[30] I V Karagounis, D Kalamida, A Mitrakas et al. Repression of the autophagic response sensitises lung cancer cells to radiation and chemotherapy. British Journal of Cancer, 115, 312-321(2016).

[31] X D Jin, X G Zheng, F F Li et al. Fragmentation level determines mitochondrial damage response and subsequently the fate of cancer cells exposed to carbon ions. Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology, 129, 75-83(2018).

[32] B Zhang, M M Davidson, T K Hei. Mitochondria regulate DNA damage and genomic instability induced by high LET radiation. Life Sciences in Space Research, 1, 80-88(2014).

[33] S P Jackson, J Bartek. The DNA-damage response in human biology and disease. Nature, 461, 1071-1078(2009).

[34] D R Green, G Kroemer. The pathophysiology of mitochondrial cell death. Science, 305, 626-629(2004).

[35] S Raha, B H Robinson. Mitochondria, oxygen free radicals, and apoptosis. American Journal of Medical Genetics, 106, 62-70(2001).

[36] K Klein, K W He, A I Younes et al. Role of mitochondria in cancer immune evasion and potential therapeutic approaches. Frontiers in Immunology, 11, 573326(2020).

[37] K P Aninditha, K J Weber, S Brons et al. In vitro sensitivity of malignant melanoma cells lines to photon and heavy ion radiation. Clinical and Translational Radiation Oncology, 17, 51-56(2019).

[38] F Schlaich, S Brons, T Haberer et al. Comparison of the effects of photon versus carbon ion irradiation when combined with chemotherapy in vitro. Radiation Oncology, 8, 260(2013).

[39] R Shavit, M Ilouze, T Feinberg et al. Mitochondrial induction as a potential radio-sensitizer in lung cancer cells - a short report. Cellular Oncology, 38, 247-252(2015).