[1] [1] Huang Z, Zhang Y, Liu R, Li Y, Rafique M, Midgley AC, Wan Y, Yan H, Si J, Wang T, Chen C, Wang P, Shafiq M, Li J, Zhao L, Kong D, Wang K. Cobalt loaded electrospun poly(ε-caprolactone) grafts promote antibacterial activity and vascular regeneration in a diabetic rat model. Biomaterials. 2022;291: 121901.10.1016/j.biomaterials.2022.121901

[2] [2] Liang Y, He J, Guo B. Functional hydrogels as wound dressing to enhance wound healing. ACS Nano. 2021;15:12687–722.10.1021/acsnano.1c04206

[3] [3] Bandyk DF. The diabetic foot: pathophysiology, evaluation, and treatment. Semin Vasc Surg. 2018;31:43–8.10.1053/j.semvascsurg.2019.02.001

[4] [4] Huang F, Lu X, Yang Y, Yang Y, Li Y, Kuai L, Li B, Dong H, Shi J. Microenvironment-based diabetic foot ulcer nanomedicine. Adv Sci. 2023;10:2203308.10.1002/advs.202203308

[5] [5] Liu S, Zhang Q, Yu J, Shao N, Lu H, Guo J, Qiu X, Zhou D, Huang Y. Absorbable thioether grafted hyaluronic acid nanofibrous hydrogel for synergistic modulation of inflammation microenvironment to accelerate chronic diabetic wound healing. Adv Healthc Mater. 2020;9:2000198.10.1002/adhm.202000198

[6] [6] Xian C, Zhang Z, You X, Fang Y, Wu J. Nanosized fat emulsion injection modulating local microenvironment promotes angiogenesis in chronic wound healing. Adv Funct Mater. 2022;32:2202410.10.1002/adfm.202202410

[7] [7] Eming Sabine A, Martin P, Tomic-Canic M. Wound repair and regeneration: mechanisms, signaling, and translation. Sci Transl Med. 2014;6:265.

[8] [8] Zhu H, Xing C, Dou X, Zhao Y, Peng Y, Feng C, Fang Y. Chiral hydrogel accelerates re-epithelization in chronic wounds via mechanoregulation. Adv Healthc Mater. 2022;11:2201032.10.1002/adhm.202201032

[9] [9] Shou Y, Le Z, Cheng HS, Liu Q, Ng YZ, Becker DL, Li X, Liu L, Xue C, Yeo NJY, Tan R, Low J, Kumar ARK, Wu KZ, Li H, Cheung C, Lim CT, Tan NS, Chen Y, Liu Z, Tay A. Mechano-activated cell therapy for accelerated diabetic wound healing. Adv Mater. 2023;35:2304638.10.1002/adma.202304638

[10] [10] Huang W, Xiao Y, Shi X. Construction of electrospun organic/inorganic hybrid nanofibers for drug delivery and tissue engineering applications. Adv Fiber Mater. 2019;1:32–45.10.1007/s42765-019-00007-w

[11] [11] Chen Y, Shafiq M, Liu M, Morsi Y, Mo X. Advanced fabrication for electrospun three-dimensional nanofiber aerogels and scaffolds. Bioact Mater. 2020;5:963–79.

[12] [12] Kong B, Liu R, Guo J, Lu L, Zhou Q, Zhao Y. Tailoring micro/nano-fibers for biomedical applications. Bioact Mater. 2023;19:328–47.

[13] [13] Yang Y, Du Y, Zhang J, Zhang H, Guo B. Structural and functional design of electrospun nanofibers for hemostasis and wound healing. Adv Fiber Mater. 2022;4:1027–57.10.1007/s42765-022-00178-z

[14] [14] Guo Y, Huang J, Fang Y, Huang H, Wu J. 1D, 2D, and 3D scaffolds promoting angiogenesis for enhanced wound healing. Chem Eng J. 2022;437: 134690.10.1016/j.cej.2022.134690

[15] [15] Ehterami A, Salehi M, Farzamfar S, Vaez A, Samadian H, Sahrapeyma H, Mirzaii M, Ghorbani S, Goodarzi A. In vitro and in vivo study of PCL/COLL wound dressing loaded with insulin-chitosan nanoparticles on cutaneous wound healing in rats model. Int J Biol Macromol. 2018;117:601–9.10.1016/j.ijbiomac.2018.05.184

[16] [16] Khan AUR, Huang K, Jinzhong Z, Zhu T, Morsi Y, Aldalbahi A, El-Newehy M, Yan X, Mo X. PLCL/Silk fibroin based antibacterial nano wound dressing encapsulating oregano essential oil: fabrication, characterization and biological evaluation. Colloids Surf B. 2020;196:111352.10.1016/j.colsurfb.2020.111352

[17] [17] Wang ML, Yu DG, Bligh SWA. Progress in preparing electrospun Janus fibers and their applications. Appl Mater Today. 2023;31: 101766.10.1016/j.apmt.2023.101766

[18] [18] Shi Y, Zhou M, Zhao S, Li H, Wang W, Cheng J, Jin L, Wang Y. Janus amphiphilic nanofiber membranes synergistically drive antibacterial and anti-inflammatory strategies for skin wound healing. Mater Des. 2023;227: 111778.10.1016/j.matdes.2023.111778

[19] [19] Zhao Y, Liu Y, Tian C, Liu Z, Wu K, Zhang C, Han X. Construction of antibacterial photothermal PCL/AgNPs/BP nanofibers for infected wound healing. Mater Des. 2023;226: 111670.10.1016/j.matdes.2023.111670

[20] [20] Oliveira MCA, Silva FAG, Costa MM, Rakov N, Oliveira HP. Curcumin-loaded electrospun fibers: fluorescence and antibacterial activity. Adv Fiber Mater. 2020;2:256–64.10.1007/s42765-020-00048-6

[21] [21] Fahimirad S, Abtahi H, Satei P, Ghaznavi-Rad E, Moslehi M, Ganji A. Wound healing performance of PCL/chitosan based electrospun nanofiber electrosprayed with curcumin loaded chitosan nanoparticles. Carbohydr Polym. 2021;259: 117640.10.1016/j.carbpol.2021.117640

[22] [22] Zhang D, Chang J. Patterning of electrospun fibers using electroconductive templates. Adv Mater. 2007;19:3664–7.10.1002/adma.200700896

[23] [23] Johnson CDL, Ganguly D, Zuidema JM, Cardinal TJ, Ziemba AM, Kearns KR, McCarthy SM, Thompson DM, Ramanath G, Borca-Tasciuc DA, Dutz S, Gilbert RJ. Injectable, magnetically orienting electrospun fiber conduits for neuron guidance. ACS Appl Mater. 2019;11:356–72.10.1021/acsami.8b18344

[24] [24] Jiang Y, Li Y, Li J, Han Y, Zhang P, Yi Z, Ke Q, Xu H. A mussel-inspired extracellular matrix-mimicking composite scaffold for diabetic wound healing. ACS Appl Bio Mater. 2020;3:4052–61.10.1021/acsabm.0c00143

[25] [25] Shalumon KT, Liao HT, Li WH, Darshan TG, Mini PA, Chen JP. Braided suture-reinforced fibrous yarn bundles as a scaffold for tendon tissue engineering in extensor digitorum tendon repair. Chem Eng J. 2023;454: 140366.10.1016/j.cej.2022.140366

[26] [26] Ren X, Han Y, Wang J, Jiang Y, Yi Z, Xu H, Ke Q. An aligned porous electrospun fibrous membrane with controlled drug delivery-an efficient strategy to accelerate diabetic wound healing with improved angiogenesis. Acta Biomater. 2018;70:140–53.10.1016/j.actbio.2018.02.010

[27] [27] Wang L, Ma J, Guo T, Zhang F, Dong A, Zhang S, Liu Y, Yuan H, Leng J. Control of surface wrinkles on shape memory PLA/PPDO micro-nanofibers and their applications in drug release and anti-scarring. Adv Fiber Mater. 2023;5:632–49.10.1007/s42765-022-00249-1

[28] [28] Yin J, Xu L, Ahmed A. Batch preparation and characterization of electrospun porous polylactic acid-based nanofiber membranes for antibacterial wound dressing. Adv Fiber Mater. 2022;4:832–44.10.1007/s42765-022-00141-y

[29] [29] Zhu J, Tang D, Lu Z, Xin Z, Song J, Meng J, Lu JR, Li Z, Li J. Ultrafast bone-like apatite formation on highly porous poly(l-lactic acid)-hydroxyapatite fibres. Mater Sci Eng C. 2020;116: 111168.10.1016/j.msec.2020.111168

[30] [30] Liu X, Chen M, Luo J, Zhao H, Zhou X, Gu Q, Yang H, Zhu X, Cui W, Shi Q. Immunopolarization-regulated 3D printed-electrospun fibrous scaffolds for bone regeneration. Biomaterials. 2021;276: 121037.10.1016/j.biomaterials.2021.121037

[31] [31] Lu Z, Wang W, Zhang J, Bártolo P, Gong H, Li J. Electrospun highly porous poly(L-lactic acid)-dopamine-SiO2 fibrous membrane for bone regeneration. Mater Sci Eng C. 2020;117: 111359.10.1016/j.msec.2020.111359

[32] [32] Zhou WY, Zhou YB, Wang SW, Wang P, Teng S. Porous and self-strengthened poly(ε-caprolactone)/calcium sulfate hemihydrate composite fibers for bone regeneration. Ceram Int. 2021;47:23814–20.10.1016/j.ceramint.2021.05.088

[33] [33] Lin Y, Xu J, Dong Y, Wang Y, Yu C, Li Y, Zhang C, Chen Q, Chen S, Peng Q. Drug-free and non-crosslinked chitosan/hyaluronic acid hybrid hydrogel for synergistic healing of infected diabetic wounds. Carbohydr Polym. 2023;314:120962.10.1016/j.carbpol.2023.120962

[34] [34] Geng C, He S, Yu S, Johnson HM, Shi H, Chen Y, Chan YK, He W, Qin M, Li X, Deng Y. Achieving clearance of drug-resistant bacterial infection and rapid cutaneous wound regeneration using an ROS-balancing-engineered heterojunction. Adv Mater. 2024;36:2310599.10.1002/adma.202310599

[35] [35] Zahid AA, Chakraborty A, Shamiya Y, Ravi SP, Paul A. Leveraging the advancements in functional biomaterials and scaffold fabrication technologies for chronic wound healing applications. Mater Horiz. 2022;9:1850–65.10.1039/D2MH00115B

[36] [36] Li Y, Wang J, Wang Y, Cui W. Advanced electrospun hydrogel fibers for wound healing. Compos Part B-Eng. 2021;223: 109101.10.1016/j.compositesb.2021.109101

[37] [37] Hamdan S, Pastar I, Drakulich S, Dikici E, Tomic-Canic M, Deo S, Daunert S. Nanotechnology-driven therapeutic interventions in wound healing: potential uses and applications. ACS Cent Sci. 2017;3:163–75.10.1021/acscentsci.6b00371

[38] [38] Zhou F, Cui C, Sun S, Wu S, Chen S, Ma J, Li CM. Electrospun ZnO-loaded chitosan/PCL bilayer membranes with spatially designed structure for accelerated wound healing. Carbohydr Polym. 2022;282: 119131.10.1016/j.carbpol.2022.119131

[39] [39] Yang F, Xue Y, Wang F, Guo D, He Y, Zhao X, Yan F, Xu Y, Xia D, Liu Y. Sustained release of magnesium and zinc ions synergistically accelerates wound healing. Bioact Mater. 2023;26:88–101.

[40] [40] Deng Y, Gao Y, Li T, Xiao S, Adeli M, Rodriguez RD, Geng W, Chen Q, Cheng C, Zhao C. Amorphizing metal selenides-based ROS biocatalysts at surface nanolayer toward ultrafast inflammatory diabetic wound healing. ACS Nano. 2023;17:2943–57.10.1021/acsnano.2c11448

[41] [41] Liu M, Wang X, Cui J, Wang H, Sun B, Zhang J, Rolauffs B, Shafiq M, Mo X, Zhu Z, Wu J. Electrospun flexible magnesium-doped silica bioactive glass nanofiber membranes with anti-inflammatory and pro-angiogenic effects for infected wounds. J Mater Chem B. 2023;11:359–76.10.1039/D2TB02002E

[42] [42] Yao J, Cheng Y, Zhou M, Zhao S, Lin S, Wang X, Wu J, Li S, Wei H. ROS scavenging Mn3O4 nanozymes for in vivo anti-inflammation. Chem Sci. 2018;9:2927–33.10.1039/C7SC05476A

[43] [43] Hu H, Yu L, Qian X, Chen Y, Chen B, Li Y. Chemoreactive nanotherapeutics by metal peroxide based nanomedicine. Adv Sci. 2021;8:2000494.10.1002/advs.202000494

[44] [44] Wang C, Li Z, Bai J. Bubble-assisted HIFU ablation enabled by calcium peroxide. J Mater Chem B. 2022;10:4442–51.10.1039/D2TB00587E

[45] [45] Li J, Yi W, Luo Y, Yang K, He L, Xu C, Deng L, He D. GSH-depleting and H2O2-self-supplying hybrid nanozymes for intensive catalytic antibacterial therapy by photothermal-augmented co-catalysis. Acta Biomater. 2023;15:588–600.10.1016/j.actbio.2022.10.050

[46] [46] Zhang Y, Liu W, Huang Y, Wang Y, Chen X, Chen Z. Bacterial biofilm microenvironment responsive copper-doped zinc peroxide nanocomposites for enhancing chemodynamic therapy. Chem Eng J. 2022;446: 137214.10.1016/j.cej.2022.137214

[47] [47] Li C, He X, Li Q, Lv M, Shen J, Jin L, He D. A photothermal-response oxygen release platform based on a hydrogel for accelerating wound healing. NPG Asia Mater. 2023;15:3.10.1038/s41427-022-00456-7

[48] [48] Seyyed-Nasrollah SA, Karimi-Soflou R, Karkhaneh A. Photo-click crosslinked hydrogel containing MgO2-loaded PLGA microsphere with concurrent magnesium and oxygen release for bone tissue engineering. Mater Today Chem. 2023;28: 101389.10.1016/j.mtchem.2023.101389

[49] [49] Deng H, Yang Z, Pang X, Zhao C, Tian J, Wang Z, Chen X. Self-sufficient copper peroxide loaded pKa-tunable nanoparticles for lysosome-mediated chemodynamic therapy. Nano Today. 2022;42: 101337.10.1016/j.nantod.2021.101337

[50] [50] Lin LS, Huang T, Song J, Ou XY, Wang Z, Deng H, Tian R, Liu Y, Wang JF, Liu Y, Yu G, Zhou Z, Wang S, Niu G, Yang HH, Chen X. Synthesis of copper peroxide nanodots for H2O2 self-supplying chemodynamic therapy. J Am Chem Soc. 2019;141:9937–45.10.1021/jacs.9b03457

[51] [51] Qi L, Huang Y, Sun D, Liu Z, Jiang Y, Liu J, Wang J, Liu L, Feng G, Li Y, Zhang L. Guiding the path to healing: CuO2-laden nanocomposite membrane for diabetic wound treatment. Small. 2023;20:2305100.10.1002/smll.202305100

[52] [52] Huang Y, Qi L, Liu Z, Jiang Y, Wang J, Liu L, Li Y, Zhang L, Feng G. Radially electrospun fibrous membrane incorporated with copper peroxide nanodots capable of self-catalyzed chemodynamic therapy for angiogenesis and healing acceleration of diabetic wounds. ACS Appl Mater Int. 2023;15:35986–98.10.1021/acsami.3c06703

[53] [53] Woodruff MA, Hutmacher DW. The return of a forgotten polymer-polycaprolactone in the 21st century. Prog Polym Sci. 2010;35:1217–56.10.1016/j.progpolymsci.2010.04.002

[54] [54] Liu L, Shang Y, Li C, Jiao Y, Qiu Y, Wang C, Wu Y, Zhang Q, Wang F, Yang Z, Wang L. Hierarchical nanostructured electrospun membrane with periosteum-mimic microenvironment for enhanced bone regeneration. Adv Healthc Mater. 2021;10:2170106.10.1002/adhm.202170106

[55] [55] Liu L, Zhang T, Li C, Jiang G, Wang F, Wang L. Regulating surface roughness of electrospun poly(ε-caprolactone)/β-tricalcium phosphate fibers for enhancing bone tissue regeneration. Eur Polym J. 2021;143: 110201.10.1016/j.eurpolymj.2020.110201

[56] [56] Qian Y, Zhou X, Zhang F, Diekwisch TGH, Luan X, Yang J. Triple PLGA/PCL scaffold modification including silver impregnation, collagen coating, and electrospinning significantly improve biocompatibility, antimicrobial, and osteogenic properties for orofacial tissue regeneration. ACS Appl Mater Int. 2019;11:37381–96.10.1021/acsami.9b07053

[57] [57] Yang HC, Waldman RZ, Wu MB, Hou J, Chen L, Darling SB, Xu ZK. Dopamine: just the right medicine for membranes. Adv Funct Mater. 2018;28:1705327.10.1002/adfm.201705327

[58] [58] Liu J, Yue Y, Wang W, Tan F, Xia H, Wang X, Qiao X, Wong PK. Facile one-step synthesis of 3D hierarchical flower-like magnesium peroxide for efficient and fast removal of tetracycline from aqueous solution. J Hazard Mater. 2020;397:122877.10.1016/j.jhazmat.2020.122877

[59] [59] Wu D, Bai Y, Wang W, Xia H, Tan F, Zhang S, Su B, Wang X, Qiao X, Wong PK. Highly pure MgO2 nanoparticles as robust solid oxidant for enhanced Fenton-like degradation of organic contaminants. J Hazard Mater. 2019;374:319–28.10.1016/j.jhazmat.2019.04.058

[60] [60] Rastinfard A, Dalisson B, Barralet J. Aqueous decomposition behavior of solid peroxides: effect of pH and buffer composition on oxygen and hydrogen peroxide formation. Acta Biomater. 2022;145:390–402.10.1016/j.actbio.2022.04.004

[61] [61] Liu B, Bian Y, Liang S, Yuan M, Dong S, He F, Gai S, Yang P, Cheng Z, Lin J. One-step integration of tumor microenvironment-responsive calcium and copper peroxides nanocomposite for enhanced chemodynamic/ion-interference therapy. ACS Nano. 2022;16:617–30.10.1021/acsnano.1c07893

[62] [62] Li X, Wu T, Zhang Z, Liu S, Cui H, Fan Z, Wang B, Hai J. Tumor microenvironment activated nanoreactors for chemiluminescence imaging-guided simultaneous elimination of breast tumors and tumor-resident intracellular pathogens. Chem Eng J. 2023;453: 139939.10.1016/j.cej.2022.139939

[63] [63] Koo S, Park OK, Kim J, Han SI, Yoo TY, Lee N, Kim YG, Kim H, Lim C, Bae JS, Yoo J, Kim D, Choi SH, Hyeon T. Enhanced chemodynamic therapy by Cu-Fe peroxide nanoparticles: tumor microenvironment-mediated synergistic Fenton reaction. ACS Nano. 2022;16:2535–45.10.1021/acsnano.1c09171

[64] [64] Gleeson SE, Kim S, Yu T, Marcolongo M, Li CY. Size-dependent soft epitaxial crystallization in the formation of blend nanofiber shish kebabs. Polymer. 2020;202: 122644.10.1016/j.polymer.2020.122644

[65] [65] Zhou X, Cheng X, Xing D, Ge Q, Li Y, Luan X, Gu N, Qian Y. Ca ions chelation, collagen I incorporation and 3D bionic PLGA/PCL electrospun architecture to enhance osteogenic differentiation. Mater Des. 2021;198: 109300.10.1016/j.matdes.2020.109300

[66] [66] Xing C, Zhu H, Dou X, Gao L, Baddi S, Zou Y, Zhao C, Peng Y, Fang Y, Feng CL. Infected diabetic wound regeneration using peptide-modified chiral dressing to target revascularization. ACS Nano. 2023;17:6275–91.10.1021/acsnano.2c10039

[67] [67] Yang Y, Zhou X, Chan Y, Wang Z, Li L, Li J, Liang K, Deng Y. Photo-activated nanofibrous membrane with self rechargeable antibacterial function for stubborn infected cutaneous regeneration. Small. 2022;18:2105988.10.1002/smll.202105988

[68] [68] Li M, Lan X, Han X, Shi S, Sun H, Kang Y, Dan J, Sun J, Zhang W, Wang J. Acid-induced self-catalyzing platform based on dextran-coated copper peroxide nanoaggregates for biofilm treatment. ACS Appl Mater. 2021;13:29269–80.10.1021/acsami.1c03409

[69] [69] Liu X, He X, Jin D, Wu S, Wang H, Yin M, Aldalbahi A, El-Newehy M, Mo X, Wu J. A biodegradable multifunctional nanofibrous membrane for periodontal tissue regeneration. Acta Biomater. 2020;108:207–22.10.1016/j.actbio.2020.03.044

[70] [70] Zhang J, Liu JJ, Zhou QH, Liu Z, Hu PY, Yuan Z, Ramakrishna S, Yang DP, Long YZ. Bifunctional CuS composite nanofibers via in situ electrospinning for outdoor rapid hemostasis and simultaneous ablating superbug. Chem Eng J. 2020;401: 126096.10.1016/j.cej.2020.126096

[71] [71] Huang C, Yang G, Zhou S, Luo E, Pan J, Bao C, Liu X. Controlled delivery of growth factor by hierarchical nanostructured core-shell nanofibers for the efficient repair of critical-sized rat calvarial defect. ACS Biomater Sci. 2020;6:5758–70.10.1021/acsbiomaterials.0c00837

[72] [72] Sheng Z, Xu Y, Tong Z, Mao Z, Zheng Y. Dual functional electrospun nanofiber membrane with ROS scavenging and revascularization ability for diabetic wound healing. Colloid Interface Sci Commun. 2022;48: 100620.10.1016/j.colcom.2022.100620

[73] [73] Zhang Y, Cui S, Cao S, Yang L, Qin G, Zhang E. To improve the angiogenesis of endothelial cells on Ti-Cu alloy by the synergistic effects of Cu ions release and surface nanostructure. Surf Coat Technol. 2022;433: 128116.10.1016/j.surfcoat.2022.128116

[74] [74] Zheng W, Zhou T, Zhang Y, Ding J, Xie J, Wang S, Wang Z, Wang K, Shen L, Zhu Y, Gao C. Simplified α2-macroglobulin as a TNF-α inhibitor for inflammation alleviation in osteoarthritis and myocardial infarction therapy. Biomaterials. 2023;301:122247.10.1016/j.biomaterials.2023.122247

[75] [75] Brockmann L, Tran A, Huang Y, Edwards M, Ronda C, Wang HH, Ivanov II. Intestinal microbiota-specific Th17 cells possess regulatory properties and suppress effector T-cells via c-MAF and IL-10. Immunity. 2023;56:2719–35.10.1016/j.immuni.2023.11.003

[76] [76] Ferre S, Baldoli E, Leidi M, Maier JAM. Magnesium deficiency promotes a pro-atherogenic phenotype in cultured human endothelial cells via activation of NFkB. Biochim Biophys Acta. 2010;1802:952–8.10.1016/j.bbadis.2010.06.016

[77] [77] Afsharian YP, Rahimnejad M. Bioactive electrospun scaffolds for wound healing applications: a comprehensive review. Polym Test. 2021;93: 106952.10.1016/j.polymertesting.2020.106952

[78] [78] Lin R, Deng C, Li X, Liu Y, Zhang M, Qin C, Yao Q, Wang L, Wu C. Copper-incorporated bioactive glass-ceramics inducing anti-inflammatory phenotype and regeneration of cartilage/bone interface. Theranostics. 2019;9:6300–13.10.7150/thno.36120

[79] [79] Guo Y, You Y, Shang FF, Wang X, Huang B, Zhao B, Lv D, Yang S, Xie M, Kong L, Du D, Luo S, Tian X, Xia Y. iNOS aggravates pressure overload-induced cardiac dysfunction via activation of the cytosolic-mtDNA-mediated cGAS-STING pathway. Theranostics. 2023;13:4229–46.10.7150/thno.84049