A high voltage and low power comparator circuit was presented. The circuit based on 05 μm CMOS IC process was designed with differential pair single ended output structure, and high voltage PMOS tail current was used to realize the purpose of reducing power consumption. The results show that the static current of the circuit is about 825 μA, the operating voltage range is 3-18 V, the input offset voltage is 5 mV, the input offset current is about 6 fA, and the input bias current is about 25 pA. The circuit is suitable for analog circuits with low power and high voltage.