Multiple evaluation of the effect of <sup>60</sup>Co-γ irradiation sterilization on the quality of <i>Fructus forsythiae</i>

Tengxiao MAO; Xinran WU; Congcong ZHANG; Long CHENG; Jiaojiao ZHENG; Qi DAI; Jiang HE

doi:10.11889/j.1000-3436.2024-0049

Journal of Radiation Research and Radiation Processing, Volume. 43, Issue 1, 010403(2025)

Multiple evaluation of the effect of ⁶⁰Co-γ irradiation sterilization on the quality of Fructus forsythiae

Tengxiao MAO1... Xinran WU1, Congcong ZHANG1, Long CHENG1, Jiaojiao ZHENG1,*, Qi DAI1 and Jiang HE2 |Show fewer author(s)

Author Affiliations

¹Key Laboratory of Chemical Quality Research and Control, Chengdu Institute For Drug Control, Chengdu 610045, China

²Key laboratory of Irradiation Preservation Sichuan Province, Sichuan Institute of Atomic Energy, Chengdu 610101, China

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Fig. 1. HPLC fingerprint chromatograms of Fructus forsythiaeirradiated by different doses of ⁶⁰Co-γ ray

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Fig. 2. Antibacterial activity against Staphylococcus aureusof water extract of Fructus forsythiae: (a) the concentration of the extract shows a good linear relationship with the diameter of the inhibition zone; (b) there is no significant difference in the diameter of the inhibition zone before and after irradiation at concentrations of 0.26 g/mL and 0.33 g/mL (p > 0.05)

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Fig. 3. Near-infrared spectrogram of Fructus forsythiaesamples (color online)

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Fig. 4. Near-infrared consistecy evaluation model of Fructus forsythiaesamples

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Table 1. Content of each constituent and the diameter of the inhibition zone for Staphylococcus aureus of the water extract of Fructus forsythiae before and after irradiation

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Table 1. Content of each constituent and the diameter of the inhibition zone for Staphylococcus aureus of the water extract of Fructus forsythiae before and after irradiation

批数 Lot number	吸收剂量 / kGy Absorbed dose	连翘酯苷I / (mg·g^-1) Forsythiaside I	连翘酯苷A / (mg·g^-1) Forsythiaside A	连翘苷 / (mg·g^-1) Forsythin	连翘水提物（0.33 mg/L）抑菌圈直径 / mm Diameter of inhibition zone for water extract of Fructus forsythiae(0.33 mg/L)
1 2	0	7.35	36.75	3.60	15.07
	5	7.33	36.82	3.65	15.11
	10	6.52^**	34.48^**	3.63	14.99
	0	7.31	35.76	3.67	15.10
	5	7.33	36.25	3.64	15.06
	10	6.34^**	34.14^**	3.64	14.95

Table 2. HPLC fingerprint chromatograms similarity of Fructus forsythiaeirradiated by different doses of ⁶⁰Co-γ ray
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Table 2. HPLC fingerprint chromatograms similarity of Fructus forsythiaeirradiated by different doses of ⁶⁰Co-γ ray
批数
Lot number
吸收剂量/ kGy Absorbed dose
0 5 10
1 1.000 0.999 0.923
2 1.000 0.999 0.936

Table 3. Effects of different doses of ⁶⁰Co-γ irradiation on the microorganism of Fructus forsythiae

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Table 3. Effects of different doses of ⁶⁰Co-γ irradiation on the microorganism of Fructus forsythiae

批数 Lot number	吸收剂量 / kGy Absorbed dose	微生物限度检查 /（CFU·g^-1） Microbial limit testing
批数 Lot number	吸收剂量 / kGy Absorbed dose	TAMC	TYMC	BGNB
1	0	3.8×10⁷	1.6×10⁶	10²<N<10³
	5	1 500	340	<100
	10	<100	<100	<100
2	0	6.2×10⁶	8.5×10⁴	10²<N<10³
	5	5 400	250	<100
	10	<100	<100	<100

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Tengxiao MAO, Xinran WU, Congcong ZHANG, Long CHENG, Jiaojiao ZHENG, Qi DAI, Jiang HE. Multiple evaluation of the effect of ⁶⁰Co-γ irradiation sterilization on the quality of Fructus forsythiae[J]. Journal of Radiation Research and Radiation Processing, 2025, 43(1): 010403

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Paper Information

Category: RADIATION TECHNOLOGY APPLICATION

Received: Jun. 29, 2024

Accepted: Sep. 12, 2024

Published Online: Mar. 13, 2025

The Author Email: ZHENG Jiaojiao (郑娇娇)

DOI:10.11889/j.1000-3436.2024-0049

Topics

laser devices and laser physics

Lasers and Laser Optics

Laser physics

laser manufacturing

Instrumentation, Measurement and Metrology

Table 1. Content of each constituent and the diameter of the inhibition zone for Staphylococcus aureus of the water extract of Fructus forsythiae before and after irradiation

Table 1. Content of each constituent and the diameter of the inhibition zone for Staphylococcus aureus of the water extract of Fructus forsythiae before and after irradiation

Table 2. HPLC fingerprint chromatograms similarity of Fructus forsythiaeirradiated by different doses of ⁶⁰Co-γ ray

Table 2. HPLC fingerprint chromatograms similarity of Fructus forsythiaeirradiated by different doses of ⁶⁰Co-γ ray

Table 3. Effects of different doses of ⁶⁰Co-γ irradiation on the microorganism of Fructus forsythiae

Table 3. Effects of different doses of ⁶⁰Co-γ irradiation on the microorganism of Fructus forsythiae

Table 1. Content of each constituent and the diameter of the inhibition zone for Staphylococcus aureus of the water extract of Fructus forsythiae before and after irradiation

Table 1. Content of each constituent and the diameter of the inhibition zone for Staphylococcus aureus of the water extract of Fructus forsythiae before and after irradiation

Table 2. HPLC fingerprint chromatograms similarity of Fructus forsythiaeirradiated by different doses of 60Co-γ ray

Table 2. HPLC fingerprint chromatograms similarity of Fructus forsythiaeirradiated by different doses of 60Co-γ ray

Table 3. Effects of different doses of 60Co-γ irradiation on the microorganism of Fructus forsythiae

Table 3. Effects of different doses of 60Co-γ irradiation on the microorganism of Fructus forsythiae

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Table 2. HPLC fingerprint chromatograms similarity of Fructus forsythiaeirradiated by different doses of ⁶⁰Co-γ ray

Table 2. HPLC fingerprint chromatograms similarity of Fructus forsythiaeirradiated by different doses of ⁶⁰Co-γ ray

Table 3. Effects of different doses of ⁶⁰Co-γ irradiation on the microorganism of Fructus forsythiae

Table 3. Effects of different doses of ⁶⁰Co-γ irradiation on the microorganism of Fructus forsythiae