Fig. 1. (a) Structure of spike proteins of seven coronaviruses (The protein structure diagram is taken from https://www.rcsb.org/); (b), (c) Vibration mode diagram of amide Ⅰ and Ⅲ peaks in N-methylacetamide (b is amide Ⅰ vibration mode; c is amide Ⅲ vibration mode)

Fig. 2. The descriptors of NMA molecular used to predict Raman shifts and intensities

Fig. 3. Root mean square deviation of NMA molecular structures

Fig. 4. Pearson correlation coefficient between NMA molecular descriptors

Fig. 5. The Raman shift (a) and intensity (b) of amide I peak and the Raman shift (c) and intensity (d) of amide Ⅲ peak were compared by deep learning model and DFT calculation

Fig. 6. Statistical distribution of bond length of seven coronaviruses spike protein backbone

Fig. 7. Statistical distribution of bond angle anddihedral angle of seven coronaviruses spike protein backbone

Fig. 8. Comparison of Raman characteristic peaks of amide Ⅰ and Ⅲ of seven coronavirus spike proteins
(a): Amide Ⅰ; (b): Amide Ⅲ

Fig. 9. Seven coronaviruses were distinguished by the frequency of amide Ⅰ and Ⅲ characteristic peaks