[1] LI Huichao, ZHAO Mingjuan, TIAN Long. Study on the therapeutic mechanism and effect of metformin com⁃bined with single high-dose radiotherapy in mice with non-small cell lung cancer[J]. Journal of Radiation Research and Radiation Processing, 40, 060301(2022).

[2] WANG Kun, SHAO Xia. Analysis on the harm and protection of ionizing radiation[J]. Shihezi Science and Technology, 29-30(2021).

[3] LI Peng, ZHU Boqiang, MAO Bomin et al. Health hazards and protective measures of medical radiation[J]. Chinese Journal of Radiological Health, 32, 590-594(2023).

[4] TANG Zheng, WEI Jinhua, ZHANG Lei et al. Effects of millimeter wave radiation on thereproductive system of male mice[J]. Journal of Radiation Research and Radiation Processing, 40, 010301(2022).

[5] ZHOU Xi, TANG Ying, SUN Huan et al. Protective effects of a Chinese medicinal formula on the spleen of irradiated mice[J]. Journal of Radiation Research and Radiation Processing, 41, 020302(2023).

[6] MA Shuiying, SHI Sha, YIN Aijun. Research overview of biological effects about ionizing radiation[J]. Northern Environment, 24, 9-13(2012).

[7] Maric S, Restin T, Muff J L et al. Citrulline, biomarker of enterocyte functional mass and dietary supplement. metabolism, transport, and current evidence for clinical use[J]. Nutrients, 13, 2794(2021).

[8] Lutgens L C H W, Deutz N E P, Gueulette J et al. Citrulline: a physiologic marker enabling quantitation and monitoring of epithelial radiation-induced small bowel damage[J]. International Journal of Radiation Oncology Biology Physics, 57, 1067-1074(2003).

[9] ZHANG Hao. Effect of L-citrulline on histology of intestinal epithelial cells and expression of MUC2 protein in mice with acute intestinal mucosal injury[D](2021).

[10] CAI Bin, LI Chunwei, ZHOU Minhong et al. Effects of citrulline on intestinal inflammation and peripheral blood mononuclear cells in rats with ulcerative colitis[J]. Chinese Journal of Gastroenterology and Hepatology, 29, 907-910(2020).

[11] XU Xiong. Effects of citrulline on ileal mucosa histology and serum diamine oxidase and D-lactic acid expression in septic rats[D](2019).

[12] ZHOU Jiqiu, XU Xiong, CHEN Jianxin et al. Protective effect of citrulline on colon of rats with sepsis and its effect on the release level of high mobility group box-1 protein[J]. Journal of Colorectal & Anal Surgery, 24, 103-108(2018).

[13] Sellmann C, Jin C J, Engstler A J et al. Oral citrulline supplementation protects female mice from the development of non-alcoholic fatty liver disease (NAFLD)[J]. European Journal of Nutrition, 56, 2519-2527(2017).

[14] Papadia C, Osowska S, Cynober L et al. Citrulline in health and disease: review on human studies[J]. Clinical Nutrition, 37, 1823-1828(2018).

[15] Cynober L. Citrulline: just a biomarker or a conditionally essential amino acid and a pharmaconutrient in critically ill patients?[J]. Critical Care, 17, 122(2013).

[16] Luiking Yvette C, Martijn P, Graham R et al. Reduced citrulline production in sepsis is related to diminished de novo arginine and nitric oxide production[J]. The American Journal of Clinical Nutrition, 89, 142-152(2009).

[17] Uyanga A V. L-瓜氨酸在鸡热应激和免疫应激中的作用及其机制[D](2022).

     Uyanga A V. The functional roles and mechanisms of L-citrulline in heat stressed and immune challenged chickens[D](2022).

[18] Maric S, Restin T, Muff J L et al. Citrulline, biomarker of enterocyte functional mass and dietary supplement, metabolism, transport, and current evidence for clinical use[J]. Nutrients, 13, 2794(2021).

[19] Häberle J, Boddaert N, Burlina A et al. Suggested guidelines for the diagnosis and management of urea cycle disorders[J]. Orphanet Journal of Rare Diseases, 7, 32(2012).

[20] López R, Moreno A, Boluda E R et al. Plasma citrulline concentration as a biomarker of intestinal function in short bowel syndrome and in intestinal transplant[J]. Anales de Pediatría, 79, 218-223(2013).

[21] Crenn P, Neveux N, Chevret S et al. Plasma L-citrulline concentrations and its relationship with inflammation at the onset of septic shock: a pilot study[J]. Journal of Critical Care, 29, 315.e1-315.e6(2014).

[22] Antunes M M, Leocádio P C L, Teixeira L G et al. Pretreatment with L-citrulline positively affects the mucosal architecture and permeability of the small intestine in a murine mucositis model[J]. Journal of Parenteral and Enteral Nutrition, 40, 279-286(2016).

[23] Villareal M O, Matsukawa T, Isoda H. L-citrulline supplementation-increased skeletal muscle PGC-1α expression is associated with exercise performance and increased skeletal muscle weight[J]. Molecular Nutrition & Food Research, 62, e1701043(2018).

[24] Arthur G, Frédéric L, Valérie C et al. Synergistic effects of citrulline supplementation and exercise on performance in male rats: evidence for implication of protein and energy metabolisms[J]. Clinical Science (London, England: 1979), 131, 775-790(2017).

[25] LI Xiabin, ZHAO Guodong, QIU Haori et al. Effects of L-citrulline on body weight and intestinal flora diversity of mice[J]. Chinese Journal of Animal Nutrition, 31, 4235-4241(2019).

[26] MA Yan, WANG Caidie, ZHAO Guodong et al. Effect of supplementing L-citrulline on reproductive performance of hu sheep and ewes[J]. China Feed, 2023, 56-61.

[27] Ho S W, El-Nezami H, Corke H et al. L-citrulline enriched fermented milk with Lactobacillus helveticus attenuates dextran sulfate sodium (DSS) induced colitis in mice[J]. The Journal of Nutritional Biochemistry, 99, 108858(2022).

[28] LI Lei, WANG Man, XU Shuogui. Research progress on intestinal injury mechanism and prevention and treatment of heat stroke[J]. Military Medicine of Joint Logistics, 34, 905-910(2020).

[29] Sellmann C, Jin C J, Engstler A J et al. Oral citrulline supplementation protects female mice from the development of non-alcoholic fatty liver disease (NAFLD)[J]. European Journal of Nutrition, 56, 2519-2527(2017).

[30] Batista M A, Nicoli J R, dos Santos Martins F et al. Pretreatment with citrulline improves gut barrier after intestinal obstruction in mice[J]. Journal of Parenteral and Enteral Nutrition, 36, 69-76(2012).

[31] Zoghroban H S, Ibrahim F M, Nasef N A et al. The impact of L-citrulline on murine intestinal cell integrity, immune response, and arginine metabolism in the face of Giardia lamblia infection[J]. Acta Tropica: Journal of Biomedical Sciences, 237, 106748(2023).

[32] Antunes M M, Leocádio P C L, Teixeira L G et al. Pretreatment with L-citrulline positively affects the mucosal architecture and permeability of the small intestine in a murine mucositis model[J]. Journal of Parenteral and Enteral Nutrition, 40, 279-286(2016).

[33] Ho S W, El-Nezami H, Corke H et al. L-citrulline enriched fermented milk with Lactobacillus helveticus attenuates dextran sulfate sodium (DSS) induced colitis in mice[J]. The Journal of Nutritional Biochemistry, 99, 108858(2022).

[34] Voevodskaya N V, Vanin A F. Gamma-irradiation potentiates L-arginine-dependent nitric oxide formation in mice[J]. Biochemical and Biophysical Research Communications, 186, 1423-1428(1992).

[35] Babicova A, Havlinova Z, Pejchal J et al. Early changes in L-arginine-nitric oxide metabolic pathways in response to the whole-body gamma irradiation of rats[J]. International Journal of Radiation Biology, 87, 1067-1073(2011).

[36] Guzik T J, Korbut R, Adamek-Guzik T. Nitric oxide and superoxide in inflammation and immune regulation[J]. Journal of Physiology and Pharmacology, 54, 469-487(2003).

[37] Giaid A, Lehnert S M, Chehayeb B et al. Inducible nitric oxide synthase and nitrotyrosine in mice with radiation-induced lung damage[J]. American Journal of Clinical Oncology, 26, e67-e72(2003).

[38] Lee K E, Kang Y S. L-Citrulline restores nitric oxide level and cellular uptake at the brain capillary endothelial cell line (TR-BBB cells) with glutamate cytotoxicity[J]. Microvascular Research, 120, 29-35(2018).

[39] Rajcic D, Baumann A, Hernández-Arriaga A et al. Citrulline supplementation attenuates the development of non-alcoholic steatohepatitis in female mice through mechanisms involving intestinal arginase[J]. Redox Biology, 41, 101879(2021).