Dosimetric difference analysis of various bolus regimens in post-mastectomy intensity modulated radiotherapy

Ruijun NIU; Yuexiao QI; Na TAO; Qing GUO; Xiyi WEI; Liying GAO; Fali TAO; Tingting LIU; Jianqiang CHENG; Shihong WEI

doi:10.11889/j.1000-3436.2022-0083

Journal of Radiation Research and Radiation Processing, Volume. 41, Issue 3, 030307(2023)

Dosimetric difference analysis of various bolus regimens in post-mastectomy intensity modulated radiotherapy

Ruijun NIU... Yuexiao QI, Na TAO, Qing GUO, Xiyi WEI, Liying GAO**, Fali TAO, Tingting LIU, Jianqiang CHENG and Shihong WEI* |Show fewer author(s)

Author Affiliations

Gansu Provincial Cancer Hospital, Lanzhou 730050, China

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Figures & Tables(4)

Table 1. Dosimetric differences in target volume between the three plans

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Table 1. Dosimetric differences in target volume between the three plans

参数 Parameter		全程5 mm 5 mm_all	半程5 mm 5 mm_half	半程10 mm 10 mm_half	F值 F value	p值 p value
CTV	D₂	5 463.22±74.27	5 512.76±86.09	5 478.66±94.81	1.289	0.286
	D₅₀	5 227.47±29.55	5 273.30±51.87	5 265.96±55.74	2.945	0.040
	D_max	5 690.94±131.11	5 731.25±115.27	5 712.56±116.97	0.549	0.651
	V₉₀	99.97±0.05	99.89±0.14	99.84±0.22	3.932	0.013
	V₉₅	99.88±0.12	99.09±2.80	99.56±0.56	1.052	0.376
	V₁₁₅	0.04±0.13	0.12±0.40	0.05±0.14	0.359	0.783
PTV	D₂	5 445.31±78.89	5 497.55±82.21	5 475.13±74.93	1.666	0.184
	D₅₀	5 192.79±30.77	5 240.94±49.98	5 225.77±47.84	3.582	0.019
	D₉₅	4 915.62±20.40	4 867.65±38.21	4 856.11±63.82	7.994	0.000
	D₉₈	4 788.22±57.80	4 543.19±238.24	4 378.27±372.13	11.738	0.000
	D_max	5 710.81±147.27	5 755.13±106.40	5 728.06±109.72	0.731	0.538
	V₉₀	99.59±0.33	98.38±0.73	98.01±0.72	31.325	0.000
	V₉₅	98.50±0.66	97.07±0.86	96.64±1.02	18.773	0.000
	V₁₁₅	0.04±0.12	0.10±0.31	0.04±0.13	0.338	0.798
	HI	0.126 4±0.023 5	0.181 9±0.049 2	0.209 7±0.075 3	10.078	0.000
	CI	0.765 0±0.034 7	0.754 6±0.046 8	0.756 9±0.043 7	0.331	0.803

Table 2. Dosimetric differences in OARs between the three plans

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Table 2. Dosimetric differences in OARs between the three plans

参数 Parameter		全程5 mm 5 mm_all	半程5 mm 5 mm_half	半程10 mm 10 mm_half	F值 F value	p值 p value
Esophagus	V₄₀	47.84±25.27	47.60±25.52	47.35±25.22	0.009	0.999
	V₄₅	24.62±17.15	25.30±18.13	24.71±17.86	0.003	1.000
	V₅₀	7.40±9.26	7.53±9.39	7.58±9.58	0.069	0.976
	D_max	5 093.56±316.00	5 082.31±314.99	5 067.44±308.62	0.032	0.992
	D_mean	3 431.63±934.12	3 453.25±932.77	3 415.94±944.94	0.004	1.000
Heart	V₃₀	6.26±1.85	6.30±1.97	6.30±1.86	0.104	0.958
	V₄₀	3.00±1.42	3.01±1.28	3.02±1.13	0.056	0.983
	D_max	4 953.44±243.31	4 976.43±242.87	4 994.56±204.18	0.494	0.688
	D_mean	935.50±211.42	922.06±172.84	916.31±165.98	0.226	0.878
Humerus head	V₅₀	1.43±2.24	1.78±2.48	1.69±2.29	0.348	0.791
	D_max	5 019.94±217.99	5 057.94±222.01	5 045.56±242.33	0.666	0.576
	D_mean	3 746.81±431.29	3 816.38±421.56	3 790.63±439.91	0.097	0.961
Lung-L	V₅	54.85±3.55	53.60±2.87	53.30±2.99	0.740	0.532
	V₁₀	36.28±2.11	34.40±5.30	35.26±2.32	1.052	0.376
	V₂₀	22.37±1.51	22.43±1.43	22.56±1.32	0.098	0.961
	V₃₀	16.61±1.25	17.71±4.60	19.70±12.58	0.722	0.543
	D_max	5 330.13±89.12	5 365.56±107.52	5 345.69±116.36	0.727	0.540
	D_mean	1 294.75±55.69	1 282.51±64.70	1 282.44±71.43	0.178	0.911
Skin	V₄₀	97.17±0.69	86.27±4.45	86.21±3.69	70.084	0.000
	V₄₅	93.06±1.44	79.37±5.59	76.19±6.77	49.143	0.000
	V₅₀	70.38±6.44	54.94±7.91	53.32±7.60	20.374	0.000
	V₅₅	1.31±2.36	2.87±3.26	1.61±1.70	1.423	0.245
	D_max	5 621.56±148.86	5 701.94±99.37	5 680.19±112.49	1.999	0.124
	D_mean	5 088.43±59.41	4 947.94±97.08	4 910.31±84.57	23.740	0.000
Thyroid	V₄₀	58.04±12.04	58.20±10.45	56.65±9.08	0.184	0.907
	V₄₅	43.77±11.07	46.01±13.37	42.11±10.66	0.484	0.694
	V₅₀	24.09±12.90	26.59±13.58	25.66±13.32	0.211	0.889
	D_max	5 364.75±171.47	5 390.56±160.79	5 370.00±152.07	0.078	0.972
	D_mean	3 983.38±362.87	4 020.38±369.59	3 998.69±365.33	0.031	0.993
Trachea	V₄₀	34.65±18.44	35.50±18.71	33.64±16.77	0.047	0.986
	V₄₅	12.26±8.95	12.31±8.75	10.58±7.62	0.213	0.887
	V₅₀	0.97±1.31	1.41±2.17	1.13±1.83	0.250	0.861
	D_max	4 889.25±259.70	4 859.19±377.31	4 919.25±297.63	0.229	0.876
	D_mean	3 311.81±693.41	3 354.75±684.05	3 324.81±676.84	0.011	0.998
Spinal cord	D_max	1 680.25±629.71	1 670.44±605.45	1 667.31±557.95	0.011	0.998
D_mean		381.06±137.97	388.38±125.57	372.69±111.53	0.588	0.625

Table 3. Differences in MU between the three plans
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Table 3. Differences in MU between the three plans
参数 Parameter 全程5 mm 5 mm_all 半程5 mm 5 mm_half 全程10 mm 10 mm_half F值 F value p值 p value
MU 15 892±1 821 19 256±1 880 19 404±1 800 12.074 0.000

Table 4. Differences in radiobiological effects between the three plans
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Table 4. Differences in radiobiological effects between the three plans
参数 Parameter 全程5 mm 5 mm_all 半程5 mm 5 mm_half 半程10 mm 10 mm_half F值 F value p值 p value
NTCP / % 1.01±0.09 1.04±0.18 1.01±0.12 6.300 0.001

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Ruijun NIU, Yuexiao QI, Na TAO, Qing GUO, Xiyi WEI, Liying GAO, Fali TAO, Tingting LIU, Jianqiang CHENG, Shihong WEI. Dosimetric difference analysis of various bolus regimens in post-mastectomy intensity modulated radiotherapy[J]. Journal of Radiation Research and Radiation Processing, 2023, 41(3): 030307

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