Journal of Radiation Research and Radiation Processing, Volume. 41, Issue 5, 050301(2023)
Effects of different courses of electrotherapy on learning, memory, and Notch signaling in a mouse model of radiation-induced brain injury
Figures & Tables(6)
Fig. 1. Effects of different courses of electricity on the morphology of neurons in the hippocampus DG region of mice (×200 times, scale 100 μm); note: K-blank group; M-model group; 1 Week-electroacupuncture group 1; 2 Week-electroacupuncture group 2; 3 Week-electroacupuncture group 3; 4 Week-electroacupuncture group 4; red arrow-cell shrinkage; blue arrow-intercellular space (color online)
Fig. 2. Effects of different courses of electrotherapy on synaptic structure in the DG region of mice hippocampus (× 30 000 times, scale 500 nm); note: red arrow: synaptic vesicles, blue arrow: PSD (color online)
Fig. 3. Effects of different courses of electrotherapy on the expression of Notch 1, Hes 1, and ASCL 1 proteins in the DG region of the hippocampus of mice
Table 1.
Effects of electroacupuncture intervention on learning and memory ability of mice with radiation-induced brain injury View tableView in ArticleTable 1.
Effects of electroacupuncture intervention on learning and memory ability of mice with radiation-induced brain injury 组别 Group 交替反应得分 Alternate response score 空白组 Blank group 0.93±0.06 模型组 Model group 0.33±0.05## 电针组1 Electroacupuncture group 1 0.42±0.11* 电针组2 Electroacupuncture group 2 0.60±0.06** 电针组3 Electroacupuncture group 3 0.66±0.06** 电针组4 Electroacupuncture group 4 0.73±0.05**
Table 2.
Effects of different courses of electrotherapy on synaptic structure of hippocampal DG region of mice View tableView in ArticleTable 2.
Effects of different courses of electrotherapy on synaptic structure of hippocampal DG region of mice 组别
Groups
突触界面率
Synaptic interface rate
PSD厚度 / nm
PSD thickness
突触间隙 / nm
Synaptic cleft
空白组Blank group 1.21±0.02 74.01±1.78 15.61±0.61 模型组Model group 0.98±0.01## 38.83±3.70## 33.05±3.03## 电针组 1 Electroacupuncture group 1 1.09±0.01** 43.08±2.34 30.53±1.05 电针组 2 Electroacupuncture group 2 1.11±0.01** 52.13±2.22** 27.16±0.92** 电针组 3 Electroacupuncture group 3 1.13±0.13** 60.70±2.48** 21.20±1.67** 电针组 4 Electroacupuncture group 4 1.19±0.02** 68.38±2.90** 17.50±1.80**
Table 3.
Different courses of electricity in mice hippocampal DG Notch1, Hes1, ASCL1 protein expression level of influence View tableView in ArticleTable 3.
Different courses of electricity in mice hippocampal DG Notch1, Hes1, ASCL1 protein expression level of influence 组别Groups Notch 1/β-actin Hes 1/β-actin ASCL 1/β-actin 空白组Blank group 0.38±0.12 0.65±0.39 1.66±0.43 模型组Model group 1.02±0.39# 1.60±0.26## 0.69±0.47# 电针组 1 Electroacupuncture group 1 0.76±0.27 1.23±0.18 1.08±0.25 电针组 2 Electroacupuncture group 2 0.61±0.22* 1.03±0.25* 1.21±0.36 电针组 3 Electroacupuncture group 3 0.39±0.11** 0.74±0.31** 1.53±0.21* 电针组 4 Electroacupuncture group 4 0.39±0.11** 0.67±0.24** 1.66±0.31**
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Yanhui LI, Xin WU, Tan WANG, Baiyan WANG, Han ZHANG, Tingyuan NIU, Yuqi NIU, Jianfeng GAO. Effects of different courses of electrotherapy on learning, memory, and Notch signaling in a mouse model of radiation-induced brain injury[J]. Journal of Radiation Research and Radiation Processing, 2023, 41(5): 050301
Paper Information
Category: Research Articles
Received: Jan. 30, 2023
Accepted: Apr. 28, 2023
Published Online: Dec. 27, 2023
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