Implementation modalities and research progress of total body irradiation

Xuming CHEN; Yi LIU; Shengyu YAO; Bing XU; Zhekai HU; Zhiwei CHEN; Zijie WANG; Guoqi ZHAO; Tingfeng CHEN; Liping WAN; Xianmin SONG; Yi XU; Yong LIU

doi:10.11889/j.1000-3436.2024-0009

Journal of Radiation Research and Radiation Processing, Volume. 42, Issue 4, 040101(2024)

Implementation modalities and research progress of total body irradiation

Xuming CHEN1... Yi LIU1, Shengyu YAO1, Bing XU1, Zhekai HU1, Zhiwei CHEN1, Zijie WANG1, Guoqi ZHAO1, Tingfeng CHEN1, Liping WAN2, Xianmin SONG2, Yi XU1,** and Yong LIU1,* |Show fewer author(s)

Author Affiliations

¹Department of Radiation Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China

²Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China

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Figures & Tables(5)

Fig. 1. Treatment location and patient position

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Fig. 2. Dose measurement

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Fig. 3. Process of blocking in the lungs: (a) determine the lead blocking position under the light field; (b) DR photography; (c) body surface line drawing

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Table 1. The main characteristics of two TBI conditioning regimens

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Table 1. The main characteristics of two TBI conditioning regimens

方案

Regimens

适应症

Indications

处方剂量

Prescription dose

备注

Note

清髓方案

Myeloablative conditioning

年龄<60岁、无合并症、既往未接受过清髓治疗、预期预后不佳或复发难治等情况的患者

Age<60, no comorbidities, no previous myeloablative regimens, expected poor prognosis or relapse

7.7~16 Gy/1~12次

7.7~16 Gy/1~12 Fractions

血液科医生根据疾病评估及综合治疗需要进行具体选择

Selected by hematologist based on disease assessment and treatment plan

非清髓

Nonmyeloablative conditioning

年龄>60岁、因基础疾病无法耐受清髓性方案、既往接受过清髓性方案治疗，预期预后良好、治疗前状态较好等情况的患者

Age>60, cannot tolerate myeloablative regimens due to comorbid conditions, previously received myeloablative regimens, expected poor prognosis, good condition before treatment

2~8 Gy/1~4次

2~8 Gy/1~4

Fractions

血液科医生根据疾病评估及综合治疗需要进行具体选择

Selected by hematologist based on disease assessment and treatment plan

Table 2. Characteristics of three TBI technologies

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Table 2. Characteristics of three TBI technologies

长距离固定野照射

Extended distance fixed field irradiation

容积旋转调强

Volumetric modulated arc therapy

分段照射

Segmented irradiation

剂量分布

Dose distribution

不可见，均匀度差

Invisible，low uniformity

可见，相对均匀

Visible，high uniformity

不可见，均匀度差

Invisible，low uniformity

治疗位置

Treatment position

拉长距离

Extended distance

常规治疗位

Routine position

拉长距离

Extended distance

照射方式

Treatment delivery

同时照射全身

Whole body simultaneously

多等中心分段

Multi-isocenter segment

分段

Segment

Tools

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Xuming CHEN, Yi LIU, Shengyu YAO, Bing XU, Zhekai HU, Zhiwei CHEN, Zijie WANG, Guoqi ZHAO, Tingfeng CHEN, Liping WAN, Xianmin SONG, Yi XU, Yong LIU. Implementation modalities and research progress of total body irradiation[J]. Journal of Radiation Research and Radiation Processing, 2024, 42(4): 040101

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