Radiation preparation and research progress of functional hydrogel wound dressings

Kun LIU; Dongxu TANG; Lili FU; Zhijun WANG; Huangqin CHEN; Yuesheng LI

doi:10.11889/j.1000-3436.2024-0020

Journal of Radiation Research and Radiation Processing, Volume. 42, Issue 5, 050101(2024)

Radiation preparation and research progress of functional hydrogel wound dressings

Kun LIU1...2, Dongxu TANG1,3, Lili FU1,2, Zhijun WANG1,3, Huangqin CHEN2,**, and Yuesheng LI34,* |Show fewer author(s)

Author Affiliations

¹School of Pharmacy, Hubei University of Science and Technology, Xianning 437100, China

²School of Stomatology and Optometry, Hubei University of Science and Technology, Xianning 437100, China

³Hubei Key Labortory of Radiation Chemistry and Functional Materials, Hubei University of Science and Technology, Xianning 437100, China

⁴Hubei Smart Healthcare Industry Technology Research Institute, Hubei University of Science and Technology, Xianning 437100, China

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Figures & Tables(9)

Fig. 1. Mechanism diagram of preparation of hydrogel dressing by radiation

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Fig. 2. Effect of different ratio of CS/Gel on coagulation performance^[14]

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Fig. 3. Schematic illustration and molecular mechanism of thrombin and thrombin-liposome loaded GelMA hydrogel for the repair of diabetic skin defects^[20]

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Fig. 4. Antibacterial mechanisms of metal and metallic oxide nanoparticles^[24]

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Fig. 5. Preparation mechanism and wound repair diagram of CS-PAA-pHEMA hydrogel^[48]

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Fig. 6. Immunostaining of microglia in the spinal cord with anti-OX-42 and anti-pp38 antibodies^[51]

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Fig. 7. Application of hydrogels wound dressings^[54-55]

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Table 1. Classification of hydrogel radiation techniques used

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Table 1. Classification of hydrogel radiation techniques used

辐射种类

Radiation type

机理

Mechanism

特点

Peculiarity

文献

Ref.

γ射线辐射

Gamma-ray

radiation

γ射线通过电离作用使水分子产生自由基，这些自由基可以夺取大分子链上的氢，从而使大分子链交联形成三维网络结构

Gamma rays cause water molecules to produce free radicals through ionization, and these free radicals can seize the hydrogen on the macromolecular chain, so that the macromolecular chain cross-linked to form a three-dimensional network structure

穿透力强，可以穿透物质并深入样品内部，辐射效率高

Strong penetration, can penetrate the material and deep inside the sample, high radiation efficiency

[9]

电子束辐射

Electron beam radiation

电子束辐射产生的高能电子通过电离和激发作用使聚合物溶液形成自由基，从而引发交联反应

The high energy electrons produced by the electron beam radiation can form free radicals in the polymer solution through ionization and excitation, thus triggering the cross-linking reaction

对射线利用率高、吸收剂量均匀、无污染

High utilization of rays, uniform absorption dose, no pollution

[10]

光辐射

Light radiation

光敏剂在特定波长的光照射下产生自由基，使聚合物分子之间产生交联反应，形成三维网络结构

The photosensitizer produces free radicals under the irradiation of specific wavelengths of light, which causes the cross-linking reaction between polymer molecules to form a three-dimensional network structure

环保、安全、操作简便

Environmental protection, safety, easy to operate

[11]

Table 2. The market status of irradiation-processed hydrogel wound dressings

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Table 2. The market status of irradiation-processed hydrogel wound dressings

品牌

Brand

商品名称（注册证号）

Product (registration number)

销售产品

Sell productst

来源

Source

优格（法国）

Urgo (France)

水胶体敷料（国械注进20163145060）

The hydrocolloid dressing (GXZJ 20163145060)

安普贴

UrgoAmp

http://www.urgo.cn/

https://www.nmpa.gov.cn/datasearch/search-result.html

保赫曼（德国）

Paul Hartmann (Germany)

水凝胶伤口敷料（国械注进20163145049）

Hydrogel wound dressings (GXZJ 20163145049)

HydroTac® transparent (MDR)

https://www.hartmann.info/zh-cn/

https://www.nmpa.gov.cn/datasearch/search-result.html

康维德（英国）

Convatec (Britain)

水胶体敷料（国械注进20163145002）

Hydrocolloid dressing (GXZJ 20163145002)

多爱肤

DuoDERM

https://www.hartmann.info/zh-cn/

https://www.nmpa.gov.cn/datasearch/search-result.html

长春吉原生物

Changchun JA Biotech

医用水凝胶创伤敷料（吉械注准20212140003）Medical hydrogel wound dressings (JXZN 20212140003)

冷宁康

Leng Ningkang

http://www.jat.net.cn/index.html

https://www.nmpa.gov.cn/datasearch/search-result.html

惠州华阳医疗

Huizhou Foryou Medical

医用水凝胶敷料（粤械注准20152140232）

Medical hydrogel dressings(YXZN 20152140232)

罗敷康

LUOFUCON

http://www.foryoumedical.com/Home.html; https://www.nmpa.gov.cn/datasearch/search-result.html

威海洁瑞

Weihai Jierui Medical

水胶体敷料（鲁械注准20172140050）

Hydrocolloid dressing (LXZN 20172140050)

洁瑞水胶体敷料

Jierui Hydrocolloid dressing

https://www.wegojierui.com/

https://www.nmpa.gov.cn/datasearch/search-result.html

南京荣岩医疗器械有限公司Nanjing Gelfeel

Medical Devices Co., Ltd.

壳聚糖水凝胶伤口敷料（苏械注准20152141106）Chitosan hydrogel wound dressing (SXZN 20152141106)

无

Without

https://www.nmpa.gov.cn/datasearch/search-result.html

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Kun LIU, Dongxu TANG, Lili FU, Zhijun WANG, Huangqin CHEN, Yuesheng LI. Radiation preparation and research progress of functional hydrogel wound dressings[J]. Journal of Radiation Research and Radiation Processing, 2024, 42(5): 050101

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