Fig. 1. SDOCT image with retinal pigment epithelium layers (RPE, solid red line), internal limiting membrane (ILM, solid green line), and choroid representation.

Fig. 2. Overview of automatic segmentation of the ILM and RPE layers in SDOCT images.

Fig. 3. Example of the ILM layer (blue line) and RPE layer (red line) segmentation with the solely intensity-based algorithm.

Fig. 4. Segmentation result of RPE (red line) and ILM (blue line) of the hybrid algorithm, which is solely a combination of intensity and graph-based algorithms after filling RPE gaps with the graph-based approach.

Fig. 5. Depiction of the ONHSD, which represents an average of perpendicular distances from a red line joining two BMO points to the ILM layer.

Fig. 6. Bland–Altman plot of the ONHSD measurement between the proposed hybrid algorithm and manual segmentation.

Fig. 7. Illustration of the (a) raw image of ONH from SDOCT of a primary open-angle glaucoma patient and (b) automatically segmented image with the hybrid algorithm of ILM (blue line) and RPE (red line) layers.