Journal of Innovative Optical Health Sciences, Volume. 2, Issue 1, 107(2009)

EFFICIENT FITTING RANGE FOR GLUCOSE MEASUREMENT WITH OPTICAL COHERENCE TOMOGRAPHY

SHU FENG, KEHONG YUAN, and DATIAN YE*
Author Affiliations
  • Graduate School at Shenzhen & Department of Biomedical Engineering Tsinghua University, China
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    Studies of non-invasive glucose measurement with optical coherence tomography (OCT) in tissue-simulating phantoms and biological tissues show that glucose has an effect on the OCT signal slope. Choosing an efficient fitting range to calculate the OCT signal slope is important because it helps to improve the precision of glucose measurement. In this paper, we study the problem in two ways: (1) scattering-induced change of OCT signal slope versus depth in intralipid suspensions with different concentrations based on Monte Carlo (MC) simulations and experiments and (2) efficient fitting range for glucose measurement in 3% and 10% intralipid. The results show that the OCT signal slope expresses a contrary change with scattering coefficient below a certain depth in high intralipid concentrations, so that there is an effective fitting depth. With an efficient fitting range from 100μm to the effective fitting depth, the precision of glucose measurement can be 4.4mM for 10% intralipid and 2.2mM for 3% intralipid.

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    SHU FENG, KEHONG YUAN, DATIAN YE. EFFICIENT FITTING RANGE FOR GLUCOSE MEASUREMENT WITH OPTICAL COHERENCE TOMOGRAPHY[J]. Journal of Innovative Optical Health Sciences, 2009, 2(1): 107

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    Paper Information

    Received: --

    Accepted: --

    Published Online: Jan. 10, 2019

    The Author Email: YE DATIAN (yedt6386@sz.tsinghua.edu.cn)

    DOI:

    CSTR:32186.14.

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