With the increase of signal frequency, bandwidth and transmission distance, the signal distortion problem brought by the low pass transmission characteristics of coaxial cable becomes serious and cannot be ignored. In this article, Wiener filtering method, an image reconstruction method that is usually employed in the field of image processing, is innovatively applied to the signal distortion compensation of coaxial cable. The input signal can be reconstructed only by using the S parameters of coaxial cable and output signal. Three different kinds of pulse signals, i.e., double exponential pulse signal, Gaussian modulated pulse signal and modulated square wave signal, transmitted in a 10 m coaxial cable were compensated. The results indicate that this method has excellent compensation performance for different kinds of signals. Moreover, compared with the commonly used attenuation compensation method, this method not only possesses high compensation accuracy, but also has outstanding computation efficiency, which is beneficial for practical application in the signal distortion compensation.