Laser & Optoelectronics Progress, Volume. 59, Issue 18, 1800001(2022)
Research Progress of Double-Helix Point Spread Function Engineering and Its Application
In double-helix point spread function (DH-PSF) engineering, the PSF of the conventional imaging system is transformed into DH-PSF using a regulation of pupil surface wavefront phase of imaging system to realize large-depth, high-precision nanoscale three-dimensional (3D) imaging. The DH-PSF is widely applied in life-science and material-science research, industrial detection, and other fields. In this study, the basic principle of the DH-PSF and the design and application methods of the DH phase mask are described in detail. Based on these, the applications of the DH-PSF to depth estimation, nanoscale 3D single-particle tracking, super-resolution fluorescence microscopy, and laser scanning fluorescence microscopy are introduced. The advantages of the DH-PSF technology in these application examples are emphasized, providing a useful reference for research in related fields. Finally, the prospects of the development direction of the DH-PSF technology and its application are discussed.
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Bo Cao, Huiqun Cao, Danying Lin, Junle Qu, Bin Yu. Research Progress of Double-Helix Point Spread Function Engineering and Its Application[J]. Laser & Optoelectronics Progress, 2022, 59(18): 1800001
Category: Reviews
Received: Feb. 15, 2022
Accepted: Mar. 17, 2022
Published Online: Aug. 22, 2022
The Author Email: Cao Huiqun (chq0524@163.com), Yu Bin (yubin@szu.edu.cn)