[1] [1] A. G. Bell, “On the production and reproduction of sound by light," Am. J. Sci. 20, 305–324 (1880).

[2] [2] P. Beard, “Biomedical photoacoustic imaging," Interface Focus 1, 602–631 (2011).

[3] [3] J. Tang, L. Xi, J. Zhou, H. Huang, T. Zhang, P. Carney, H. Jiang, “Noninvasive high-speed photoacoustic tomography of cerebral hemodynamicsin awake-moving rats," J. Cereb. Blood Flow Metab. 35, 1224–1232 (2015).

[4] [4] D. Wu, L. Huang, M. S. Jiang, H. Jiang, “Contrast agents for photoacoustic and thermoacoustic imaging: A review," Int. J. Mol. Sci. 15, 23616–23639 (2014).

[5] [5] A. Taruttis, S. Morscher, N. C. Burton, D. Razansky, V. Ntziachristos, “Fast multispectral optoacoustic tomography (MSOT) for dynamic imaging of pharmacokinetics and biodistribution in multiple organs," Plos One 7, e30491 (2012).

[6] [6] H. Jiang, Photoacoustic Tomography, CRC Press (2014).

[7] [7] L. Xi, S. R. Grobmyer, L. Wu, R. Chen, G. Zhou, L. G. Gutwein, J. Sun, W. Liao, Q. Zhou, H. Xie, H. Jiang, “Evaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging," Opt. Express 20, 8726–8731 (2012).

[8] [8] M. Nasiriavanaki, J. Xia, H. Wan, A. Q. Bauer, J. P. Culver, L. V. Wang, “High-resolution photoacoustic tomography of resting-state functional connectivity in the mouse brain," Proc. Natl. Acad. Sci. 111, 21 (2014).

[9] [9] D. Wu, J. Yang, G. Zhang, H. Jiang, “Noninvasive in vivo monitoring of collagenase induced intracerebral hemorrhage by photoacoustic tomography," Biomed. Opt. Exp. 8, 2276–2286 (2017).

[10] [10] D. Wu, X. Guo, R. Cui, M. Wu, Q. Shang, H. Jiang, “In vivo hemodynamic visualization of berberineinduced effect on the cerebral cortex of a mouse by photoacoustic tomography," Appl. Opt. 58, 1–8 (2019).

[11] [11] P. Zhang, L. Li, L. Lin, P. Hu, J. Shi, Y. He, L. Zhu, Y. Zhou, L. V. Wang, “High resolution deep functional imaging of the whole mouse brain by photoacoustic computed tomography in vivo," J. Biophoton. 11, e201700024 (2018).

[12] [12] S. Liu et al., “Electromagnetic–acoustic sensing for biomedical applications," Sensors 18(10), 3203 (2018).

[13] [13] D. Wang, Y. Wu, J. Xia, “Review on photoacoustic imaging of the brain using nanoprobes," Neurophotonics 3(1), 010901 (2016).

[14] [14] L. Nie, Z. Guo, L. V. Wang, “Photoacoustic tomography of monkey brain using virtual point ultrasonic transducers," J. Biomed. Opt. 16(7), 076005 (2011).

[15] [15] X. Wang, D. L. Chamberland, G. Xi, “Noninvasive reflection mode photoacoustic imaging through infant skull toward imaging of neonatal brains," J. Neurosci. Meth. 168(2), 412–421 (2008).

[16] [16] X. Wang et al., “Reflection mode photoacoustic imaging through infant skull toward noninvasive imaging of neonatal brains," J. Neurosci. Meth. 168(2), 412–421 (2009).

[17] [17] A. Hariri et al., “Functional photoacoustic tomography for neonatal brain imaging: Developments and challenges," Proc. Photons Plus Ultrasound: Imaging & Sensing. International Society for Optics and Photonics, p. 10642Z (2017).

[18] [18] S. Herrmann et al., “Cerebral blood oxygenation measurements in neonates with optoacoustic technique," Soc. Photo-Opt. Instrum. Eng. (SPIE) Conf. Series, p. 100640Q (2017).

[19] [19] C. Huang, “Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data," J. Biomed. Opt. 17(6), 066016 (2012).

[20] [20] A. R. Mohammadi-Nejad et al., “Neonatal brain resting-state functional connectivity imaging modalities," Photoacoustics S2213597917300368 (2018).

[21] [21] K. Kim et al., “Photoacoustic imaging of early inflammatory response using gold nanorods," Appl. Phys. Lett. 90(22), 223901 (2007).

[22] [22] H. W. Yang et al., “Magnetic gold-nanorod/PNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy," Biomaterials 34, 5651–5660 (2013).

[23] [23] P. H. Wang et al., “Gold-nanorod contrast-enhanced photoacoustic micro-imaging of focused-ultrasound induced blood-brain-barrier opening in a rat model," J. Biomed. Opt. 17(6), 061222 (2012).

[24] [24] P. C. Li et al., “In vivo photoacoustic molecular imaging with simultaneous multiple selective targeting using antibody-conjugated gold nanorods," Opt. Exp. 16, 18605–18615 (2008).

[25] [25] J. E. Millstone et al., “Observation of a quadrupole plasmon mode for a colloidal solution of gold nanoprisms," J. Am. Chem. Soc. 127, 5312–5313 (2005).

[26] [26] P. K. Jain et al., “Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: Applications in biological imaging and biomedicine," J. Phys. Chem. B 110, 7238–7248 (2006).

[27] [27] C. M. Chuang et al., “Acupuncture stimulation at Baihui acupoint reduced cerebral infarct and increased dopamine levels in chronic cerebral hypoperfusion and ischemia-reperfusion injured Sprague-Dawley rats," Am. J. Chin.Med. 35(5), 779–791 (2007).

[28] [28] Y. F. Qian et al., “Effects of acupuncture at different acupoints on cerebral blood flow in cerebral ischemia model rats," Zhongguo Zhenjiu 29(3), 213–216 (2009).

[29] [29] H. Xu et al., “Effects of acupuncture at Baihui (DU20) and Zusanli (ST36) on the expression of heat shock protein 70 and tumor necrosis factor α in the peripheral serum of cerebral ischemia-reperfusioninjured rats," Chin. J. Integr. Med. 20(5), 369–374 (2014).

[30] [30] B. Zhu, Scientific Foundations of Acupuncture & Moxibustion, Qingdao Press (1998).

[31] [31] B. Z. Chen et al., “Photoacoustic imaging of cerebral hypoperfusion during acupuncture," Biomed. Opt. Exp. 6(9), 3225–3234 (2015).

[32] [32] T. Li et al., “Photoacoustic imaging of acupuncture effect in small animals," Biomed. Opt. Exp. 6(2), 433–442 (2015).

[33] [33] J. Yang et al., “Photoacoustic microscopy of electronic acupuncture (EA) effect in small animals," J. Biophoton. 10(2), 217 (2016).

[34] [34] W. Dan, H. Jiang, “Contrast enhanced photoacoustic tomograpgy of living mouse brain using combined acupuncture and contrast agents," Acta Laser Biol. Sin. 27(2), 133–141 (2018).

[35] [35] G. Li et al., “Cortical activations upon stimulation of the sensorimotor-implicated acupoints," Magn. Reson. Imaging. 22(5), 639–644 (2004).

[36] [36] D. Alimi, A. Geissmann, D. Gardeur, “Functional MRI of the human brain following auricular stimulation," Med. Acupuncture. 13(2), 64 (2009).

[37] [37] C. M. Siedentopf et al., “Functional magnetic resonance imaging detects activation of the visual association cortex during laser acupuncture of the foot in humans," Neurosci. Lett. 327(1), 53–56 (2002).

[38] [38] S. S. Yoo et al., “Modulation of cerebellar activities by acupuncture stimulation: Evidence from fMRI study," Neuroimage 22(2), 932–940 (2004).

[39] [39] Z. H. Cho et al., “New findings of the correlation between acupoints and corresponding brain cortices using functional MRI," Proc. Natl. Acad. Sci. 95(5), 2670–2673 (1998).

[40] [40] W. T. Zhang et al., “Evidence from brain imaging with fMRI supporting functional specificity of acupoints in humans," Neurosci. Lett. 354(1), 50–53 (2004).

[41] [41] Y. Shifang, N. Mofan, W. Ling, “Hemodynamics effect of negative pressure on ischemic extremity," China J. Mod. Med. 11, 010 (2003).

[42] [42] H. Maeda, H. Nakamura, J. Fang, “The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo," Adv. Drug Deliv. Rev. 65(1), 71–79 (2013).

[43] [43] H. Jiang et al., “Related method of selective opening blood brain barrier," Med. Recapitulate 11, 023 (2010).

[44] [44] K. Linnet, T. B. Ejsing, “A review on the impact of P-glycoprotein on the penetration of drugs into the brain. Focus on psychotropic drugs," Eur. Neuropsychopharmacol 18(3), 157–169 (2008).

[45] [45] M. A. Deli, “Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery," Biochim. Biophys. Acta 1788(4), 892–910 (2009).

[46] [46] E. Preston et al., “Graded reversible opening of the rat blood-brain barrier by intracarotid infusion of sodium caprate," J. Neurosci. Meth. 168(2), 443–449 (2008).

[47] [47] R. Singh, J. W. Lillard Jr., “Nanoparticle-based targeted drug delivery," Exp. Mol. Pathol. 86(3), 215–223 (2009).

[48] [48] L. Liu et al., “Biologically active core/shell nanoparticles self-assembled from cholesterol-terminated PEG-TAT for drug delivery across the blood-brain barrier," Biomaterials 29(10), 1509–1517 (2008).

[49] [49] F. Y. Yang, P. Y. Lee, “E±ciency of drug delivery enhanced by acoustic pressure during blood-brain barrier disruption induced by focused ultrasound," Int. J. Nanomed. 7, 2573–2582 (2012).

[50] [50] Y. C. Kuo, C. Y. Kuo, “Electromagnetic interference in the permeability of saquinavir across the blood-brain barrier using nanoparticulate carriers," Int. J. Pharm. 351(1/2), 271–281 (2008).

[51] [51] Y. Wu, G. L. Liu, “Radiotherpy-induced Bloodbrain Barrier disruption and its implication for chemotherapy," Chin. J. Neuro-Oncol. 5(1), 63–65 (2007).

[52] [52] K. P. Tan, X. M. Lin, “Research and development tendency on Blood-brain Barrier with Chinese Herbs and acupuncture," Chin. Arch. Traditional Chin. Med. 25(11), 2283–2285 (2007).

[53] [53] J. Chen et al., “Gold nanocages: Bioconjugation and their potential use as optical imaging contrast agents," Nano Lett. 5(3), 473–477 (2005).

[54] [54] W. C. W. Chan et al., “Luminescent quantum dots for multiplexed biological detection and imaging," Curr. Opin. Biotechnol. 13(1), 40–46 (2002).

[55] [55] X. Gao et al., “In vivo molecular and cellular imaging with quantum dots," Curr. Opin. Biotechnol. 16(1), 63–72 (2005).

[56] [56] X. Feng, F. Gao, Y. Zheng, “Thermally modulated photoacoustic imaging with super-paramagnetic iron oxide nanoparticles," Opt. Lett. 39(12), 3414–3417 (2014).

[57] [57] Y. Jin et al., “Multifunctional nanoparticles as coupled contrast agents," Nat. Commun. 1, 41 (2010).

[58] [58] A. De La Zerda et al., “Carbon nanotubes as photoacoustic molecular imaging agents in living mice," Nat. Nanotechnol. 3(9), 557–562 (2008).

[59] [59] S. Zanganeh et al., “Photoacoustic imaging enhanced by indocyanine green-conjugated single-wall carbon nanotubes," J. Biomed. Opt. 18(9), 096006 (2013).

[60] [60] P. K. Avti et al., “Detection, mapping, and quanti fication of single walled carbon nanotubes in histological specimens with photoacoustic microscopy," PLoS One 7(4), e35064 (2012).

[61] [61] V. P. Nguyen et al., “Enhancement of high-resolution photoacoustic imaging with indocyanine greenconjugated carbon nanotubes," Jpn. J. Appl. Phys. 54(7S1), 07HF04 (2015).

[62] [62] S. K. Maji et al., “Upconversion nanoparticles as a contrast agent for photoacoustic imaging in live mice," Adv. Mater. 26(32), 5633–5638 (2014).

[63] [63] J. Chen et al., “Gold nanocages: Engineering their structure for biomedical applications," Adv. Mater. 17(18), 2255–2261 (2005).

[64] [64] Y. Wang et al., “Photoacoustic tomography of a nanoshell contrast agent in the in vivo rat brain," Nano Lett. 4(9), 1689–1692 (2004).

[65] [65] W. Lu et al., “Photoacoustic imaging of living mouse brain vasculature using hollow gold nanospheres," Biomaterials 31(9), 2617–2626 (2010).

[66] [66] G. Xu et al., “Theranostic quantum dots for crossing blood-brain barrier in vitro and providing therapy of HIV-associated encephalopathy," Front. Pharmacol. 4, 1–8 (2013).

[67] [67] S. Hanada et al., “Cell-based in vitro blood-brain barrier model can rapidly evaluate nanoparticles' brain permeability in association with particle size and surface modification," Int. J. Mol. Sci. 15(2), 1812–1825 (2014).

[68] [68] M. K. Garcia et al., “Systematic review of acupuncture in cancer care: A synthesis of the evidence," J. Clin. Oncol. 31(7), 952–960 (2013).

[69] [69] J. Liu et al., “Probing low-copy-number proteins in a single living cell," Angewandte Chemie Int. Ed. 55(42), 13215–13218 (2016).

[70] [70] W. Zhu, G. Xi, J. Ju, “Effect of acupuncture and Chinese medicine treatment on brain dopamine level of MPTP-lesioned C57BL mice," Acupuncture Res. 21(4), 46 (1996).

[71] [71] J. Chen, “Influence of acupuncture on serum growth hormone level in patients with type II diabetes," Acupuncture Res. 26(4), 310–313 (2001).

[72] [72] Y. Shi et al., “Effects of acupuncture combined with medicine on the expression of IFN-γ and IL-12 of colonic mucous membrane in ulcerative colitis rats," Acupuncture Res. 30(4), 215–218 (2005).

[73] [73] J. J. Cui et al., “Discussion on the novel clues for studying the underlying mechanisms of acupunctureinduced potentiation of the curative effect of medicines," Acupuncture Res. 35(2), 146–150 (2010).

[74] [74] Y. Chen, W. Jia, Z. Cheng, “Effects of electroacupuncture on tropism of effective component of pubescent angelica root in the rat with adjuvant arthritis," Chin. Acupuncture Moxibust. 24(1), 59–61 (2004).

[75] [75] Y. H. Gu, H. Z. Jin, S. D. Li, “The influence of acupuncture on the intracorporeal metabolism of tripterygium wilfordii in rate with adjuvant arthritis," Shanghai J. Acupuncture Moxibust. 20(5), 41–43 (2001).

[76] [76] S. Zhang, H. Niu, “The effect of acupoint injection of capsaicin on the neurogenic inflammation induced by primary afferent reflexs," J. Xian Med. Univ. 21(1), 6–8 (2000).

[77] [77] Z. Cheng, Y. Chen, L. Zhang, “Experimental study on effect of acupuncture on tropism of effective compositions of the Chinese drug in the rat," Chin. Acupuncture Moxibust. 22(1), 51–53 (2002).

[78] [78] T. Zhang, C. Gao, Y. Guo, “Effects of moxibustion on the function ofMDR gene product, P-glycoprotein (P-170)," Acupuncture Res. 19(2), 69–71 (1994).

[79] [79] E. Pinter, J. Szolcsanyi, “Plasma extravasation in the skin and pelvic organs evoked by antidromic stimulation of the lumbosacral dorsal roots of the rat," Neurosci. 68(2), 603–614 (1995).

[80] [80] J. Fang et al., “Neurogenic inflammation evoked by stimulation of the acupoint through drr," J. Xian Med. Univ. 1999(2), 175 (1999).

[81] [81] D. Cao, H. Niu, Z. Yan, “Neurogenic inflammation of the visceral organs evoked by electrical stimulation of acupoint in rats," Chin. Acupuncture Moxibust. 21(11), 662–664 (2001).

[82] [82] S. Zhang, H. Niu, S. Jiang, “Nerogenic inflammation evoked by stimulation of acupoint through long axon reflex," J. Xian Med. Univ. 20(4), 438–440 (1999).

[83] [83] X. C. Yu et al., “Cross-talk between cardiac kappaopioid and beta-adrenergic receptors in developing hypertensive rats," J. Mol. Cell. Cardiol. 31(3), 597 (1999).

[84] [84] J. Gao et al., “Acupuncture pretreatment protects heart from injury in rats with myocardial ischemia and reperfusion via inhibition of the β-adrenoceptor signaling pathway," Life Sci. 80(16), 1484–1489.