Spectroscopic Study on Interaction of Famotidine with Bovine Serum Albumin

T/K	Linear equationof Stern-Volmer	Correlationcoefficient	Quenching constantK_SV /(10⁴ L·mol^-1)	Quenching rate constantK_q /(L·mol^-1·s^-1)
306	F₀/F=1.0128+7.773×10⁴ $\begin{matrix} [Q] \end{matrix}$	0.99023	7.773×10⁴	7.773×10¹²
314	F₀/F=1.01207+6.15×10⁴ $\begin{matrix} [Q] \end{matrix}$	0.99754	6.15×10⁴	6.15×10¹²

Table 2. Apparent binding constant and number of binding sites of famotidine-BSA system

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Table 2. Apparent binding constant and number of binding sites of famotidine-BSA system

T/K	Linear equation	Correlationcoefficient R²	Number ofbinding sites n	Apparent binding constantK_A /(L·mol^-1)
306	lg $\begin{matrix} [(F_{0} - F) / F] \end{matrix}$ =4.99392+1.01904 lg $\begin{matrix} [Q] \end{matrix}$	0.99544	1.01904	9.861×10⁴
314	lg $\begin{matrix} [(F_{0} - F) / F] \end{matrix}$ =4.59005+0.95886 lg $\begin{matrix} [Q] \end{matrix}$	0.99926	0.95886	3.891×10⁴

Table 3. Thermodynamic parameter table
View table
Table 3. Thermodynamic parameter table
T/K K_A /(L·mol^-1) ΔH /(kJ·mol^-1) ΔG /(kJ·mol^-1) ΔS /(J·mol^-1·K^-1)
306 9.861×10⁴ -93.149 -29.254 -208.78
314 3.891×10⁴ -93.149 -27.591 -208.78

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Bo Yu, Xiufeng Lan, Lin Zhang, Ruping Zou, Qi Chen. Spectroscopic Study on Interaction of Famotidine with Bovine Serum Albumin[J]. Laser & Optoelectronics Progress, 2018, 55(4): 043003

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Paper Information

Category: Spectroscopy

Received: Sep. 26, 2017

Accepted: --

Published Online: Sep. 11, 2018

The Author Email: Lan Xiufeng (orchidxf@nuaa.edu.cn)

DOI:10.3788/LOP55.043003

Topics

laser devices and laser physics

Lasers and Laser Optics

Laser physics

laser manufacturing

Instrumentation, Measurement and Metrology

Table 1. Stern-Volmer equation, quenching constant and quenching rate constant of famotidine-BSA system

Table 1. Stern-Volmer equation, quenching constant and quenching rate constant of famotidine-BSA system

Table 2. Apparent binding constant and number of binding sites of famotidine-BSA system

Table 2. Apparent binding constant and number of binding sites of famotidine-BSA system

Table 3. Thermodynamic parameter table

Table 3. Thermodynamic parameter table