Laser & Optoelectronics Progress, Volume. 56, Issue 4, 040001(2019)

Research Progress on Photodynamic Therapy for Gastrointestinal Diseases

Jiawen Wang1, Ge Hong2, and Tianjun Liu2、*
Author Affiliations
  • 1 Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
  • 2 Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
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    Figures & Tables(3)
    • Table 1. In vitro study of PDT for gastrointestinal diseases

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      Table 1. In vitro study of PDT for gastrointestinal diseases

      DiseaseYearPhotosensitizerCell line or bacteriumReference
      Gastric cancer2011H2TFPC-SGlcMKN28, MKN45, HT29, HCT116Ref. [7]
      Gastric cancer2015α-PhSPcZnSGC-7901Ref. [8]
      Gastric cancer2015DTPMGC-803, MGC803/PARef. [9]
      Gastric cancer20165-ALAMKN-45Ref. [10]
      Gastric cancer2017Trast:PorphHER2-positive cellRef. [11]
      Gastric cancer2017AESGC-7901Ref. [12]
      Gastric cancer2018F127-APoG2@AlPcSSGC-7901Ref. [13]
      Colon cancer2009DH-Ⅱ-24HCT116Ref. [14]
      Colon cancer2017TiO2-ZnPcHT29Ref. [15]
      Colon cancer2017FA-Fe2O3HCT116Ref. [16]
      Colon cancer2013HPPH-CDColon26Ref. [17]
      Rectal cancer2013TMPHCT116Ref. [18]
      Colon cancer20155-ALASW620Ref. [19]
      Colon cancer2015Ce6SW620Ref. [20]
      Rectal cancer2017HYHT-29, HCT116Ref. [21-22]
      Rectal cancer2018PpIXHCT116Ref. [23]
      Colon cancer2018m-THPCSW480, SW620Ref. [24]
      Colon cancer2016HYHCT116, HCT8Ref. [25]
      Rectal cancer2017m-THPCHCT116Ref. [26]
      Gastritis2010MBHP26695Ref. [27]
      Gastritis2013PSMHPRef. [28]
      Enteritis2016Au NRs@SiO2-ICGEscherichia coli LF82Ref. [29]
    • Table 2. In vivo study of PDT for gastrointestinal diseases

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      Table 2. In vivo study of PDT for gastrointestinal diseases

      DiseaseYearPhotosensitizerModeling cellModeling animalReference
      Gastric cancer20085-ALAMGC-803SPF nude miceRef. [30]
      Gastric cancer2010TalaporfinMKN-45BALB/c nude miceRef. [31]
      Gastric cancer2011H2TFPC-SGlcHT29, HT116BALB/c nude miceRef. [7]
      Gastric cancer2018G-Ce6CT26BALB/c nude miceRef. [32]
      Gastric cancer20135-ALAMKN-45BALB/c nude miceRef. [33]
      Gastric cancer2016TPPSGC-7901BALB/c nude miceRef. [34]
      Gastric cancer2018Ce6MGC-803BALB/c nude miceRef. [35]
      Colon cancer2011HYCT26BALB/c nude miceRef. [36]
      Colon cancer2011IY69Colon26BALB/c nude miceRef. [37]
      Colon cancer20115-ALAColon26BALB/c nude miceRef. [38]
      Colon cancer2012HMMECT26BALB/c nude miceRef. [39]
      Colon cancer2013FullereneCT26-lucBALB/c nude miceRef. [40]
      Colon cancer2013DeuteporfinHCT-116BALB/c nude miceRef. [41]
      Rectal cancer2016HMMEVX2RabbitRef. [42]
      Colon cancer2017PSSW620SCID miceRef. [43]
      Colon cancer2018m-THPCHT-29BALB/c nude miceRef. [44]
      Gastritis1996MB, TBO, HpD, Pc, 5-ALAHPAdult ferret, waster miceRef. [45]
      Gastritis2002TPyPHPMale ferretRef. [46]
      Enteritis20115-ALAT-cellSCID miceRef. [47]
      Enteritis2015m-THPCDSSC57/BL/6 miceRef. [48]
    • Table 3. Clinical research of PDT for gastrointestinal diseases

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      Table 3. Clinical research of PDT for gastrointestinal diseases

      DiseaseYearNumber of patientsPhotosensitizerReference
      Gastric cancer2008225-ALARef. [49]
      Gastric cancer20141Talaporfin sodiumRef. [50]
      Gastric cancer201847PhotofrinRef. [51]
      Colorectal cancer198614HpDRef. [52]
      Colorectal cancer200524MTHPBCRef. [53]
      Colon cancer200620PhotofrinRef. [54]
      Colorectal cancer201640PhotoffinRef. [55]
      Colorectal cancer201623PhotofrinRef. [56]
      Colorectal cancer20171205-ALA, HPDRef. [57]
      Gastritis2002135-ALARef. [58]
      Gastritis200510PpIX, coproporphyrinRef. [59]
      Factitial proctitis19983HPDRef. [60]
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    Jiawen Wang, Ge Hong, Tianjun Liu. Research Progress on Photodynamic Therapy for Gastrointestinal Diseases[J]. Laser & Optoelectronics Progress, 2019, 56(4): 040001

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    Paper Information

    Category: Reviews

    Received: Jul. 15, 2018

    Accepted: Sep. 4, 2018

    Published Online: Jul. 31, 2019

    The Author Email: Liu Tianjun (liutianjun@hotmail.com)

    DOI:10.3788/LOP56.040001

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