Acta Photonica Sinica, Volume. 50, Issue 10, 1017002(2021)
Research Progress of Raman Spectroscopy in Medical Laboratory Science（Invited）
Figures & Tables(9)
Fig. 3. Raman spectroscopic apparatus for noninvasive glucose measurement［49］
Fig. 4. Raman spectra of Alzheimer's disease patients and healthy people ［50］
Fig. 5. Detection of macroscopic bone by spatial displacement Raman technique［57］
Table 1. Summary and comparison of Raman related techniques
View tableView in ArticleTable 1. Summary and comparison of Raman related techniques
Raman related
technology
The principle Advantages & disadvantages Application Reference The traditional
Raman
The frequency of the scattered photon is different from that of the incident photon The system is relatively simple；low sensitivity Drug and food
testing
［ 23 -25 ］Surface Enhanced Raman Scattering（SERS） Use interactions between molecules and coarse metal nanoparticles to enhance Raman signals Signal enhancement；SERS enhanced reagent is required，which may change the spectrum of endogenous molecules Tumor edge detection ［ 26 -27 ］Coherent anti-Stokes Raman Spectroscopy（CARS） The two beams of incident light illuminate the sample and interact to produce an anti-Stock market Signal enhancement；the equipment is expensive and has a strong non-resonant background It is sensitive to C-H bond and lipid detection ［ 28 -29 ］Stimulated Raman Spectroscopy
（SRS）
Like CARS，nonlinear interaction between molecules and lasers Signal enhancement，fast imaging；equipment expensive Cell lipid and protein signals were studied by simulated HE staining ［ 29 -31 ］Resonant Raman Spectroscopy（RRS） The excitation wavelength is matched with the molecular electron transition，so the vibration mode is enhanced Signal enhancement，shorten detection time；lasers with continuously adjustable frequencies are required Non-destructive detection of pigment molecules such as carotenoids ［ 14 ］Spatially Offset
Raman Spectroscopy
（SORS）
The scattered light at different depths of the sample produces different shifts Effectively inhibit fluorescence，provides in-depth organizational information；complex data processing The application of urinary system，bone，breast and other diseases ［ 32 -34 ］
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Qi ZENG, Rui LIU, Nan WANG, Tingting ZENG, Xueli CHEN. Research Progress of Raman Spectroscopy in Medical Laboratory Science（Invited）[J]. Acta Photonica Sinica, 2021, 50(10): 1017002
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Received: Jul. 20, 2021
Accepted: Aug. 19, 2021
Published Online: Nov. 3, 2021
The Author Email: CHEN Xueli (xlchen@xidian.edu.cn)
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