Journal of Inorganic Materials, Volume. 36, Issue 1, 9(2021)

Porous Carbon Nanomaterials Based Tumor Targeting Drug Delivery System: a Review

Xiaokun CHENG1...2, Yue ZHANG1, Haijun Lü1, Xinying LIU2, Senlin HOU3 and Aibing CHEN1,* |Show fewer author(s)
Author Affiliations
  • 1College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China
  • 2Institute for the Development of Energy for African Sustainability, University of South Africa, Private Bag X6, Johannesburg 1710, South Africa
  • 3The Second Hospital of Hebei Medical University, Bilio-Pancreatic Endoscopic Surgery Department, Shijiazhuang 050000, China
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    Figures & Tables(15)
    Schematic illustration of template method for synthesis of PCN[41]
    Schematic illustration of direct pyrolysis methods for synthesis of porous carbon nanomaterials (PCN) (a) Preparation of MOF and porous carbon (PC)[58]; (b) Preparation of PC from plant tissue[59]; (c) Preparation of PC from PAN-co-PPy[60]; (d) Preparation of PC from PMMA-co-PS[61]
    (a) Schematic illustration of the preparation of DOX and FA conjugate with f-PCN to form CB-DOX/FA, and (b) the loading of DOX inside the pores and at the surface of functionalized PCN (f-PCN)[71]
    Schematic preparation of DOX loaded on oxide mesoporous carbon nanospheres (OMCN) and its channel capped by the interaction of π-π[75]
    Schematic illustration of preparing combined administration of (a) hierarchical hybrid dual-pore core-shell mesoporous carbon@silica[81] and (b) PHCNs-PEI-PEG for drug and gene co-loading[82] DOX: doxorubicin; PEI; polyethyleneimine; PEG: poly (ethylene glycol); RF: resorcinlo-formaldehyde
    Schematic illustration of pH-responsive controlled release of ZnO-gated MCNs[87]
    Schematic illustration of enzyme-responsive of porous carbon obtained from ZIF pyrolysis [35]
    Schematic illustration of modified porous hollow carbon spheres and the photothermal therapy[98]
    Schematic illustration of MCNs coated Fe3O4 nanoparticles and DOX loaded[102]
    Schematic preparation of MCN responsive controlled release by pH and glutathione[105]
    Schematic illustration of construction of pH and magnetic composite sensitive materials by flower-like porous carbon composite (FPCS)[106]
    Schematic illustration of construction drug delivery by pH and magnetic composite sensitive[108]
    Schematic preparation of stimuli-responsive MHPCNs based drug delivery system for synergistic pH, glutathione and photothermal of tumor chemotherapy[110]
    • Table 1.

      多孔碳纳米材料的制备方法

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      Table 1.

      多孔碳纳米材料的制备方法

      PreparationBasic stepsRef.
      Hard template methodImpregnate the preformed hard template with carbon source, then remove the template after pyrolysis at a high temperature[29-30]
      Soft template methodThrough surfactant assembly, the template is removed after pyrolysis at high temperature[31-33]
      Direct pyrolysis methodDirect pyrolysis of carbon precursors, such as MOF, biomass, ionic liquid or polymer[34-37]
      Chemical vapor deposition methodIntroducing two or more gaseous carbon precursors into the tubular quartz reactor, carbon materials obtained through pyrolysis[38-40]
    • Table 2.

      多孔碳纳米材料构建抗肿瘤药物靶向传递系统

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      Table 2.

      多孔碳纳米材料构建抗肿瘤药物靶向传递系统

      StructureResponse modesDrugs>啊.
      Porous carbon spherepHMitoxantrone HCl[87]
      Porous carbon spherepHDoxorubicin[26]
      Porous carbon sphereSpecific enzymeDoxorubicin[91]
      Porous carbon derived from ZIFSpecific enzymeMethylene blue[35]
      Porous carbon sphereRedox potentialDoxorubicin[93]
      Hollow porous carbon sphereNear infraredDoxorubicin[82]
      Porous carbon sphereNear infraredDoxorubicin[98]
      Porous carbon sphere coated with Fe3O4MagneticDoxorubicin[102]
      Mesoporous carbon spherepH-redox potentialDoxorubicin[104][105]
      Porous carbon spherepH-magneticDoxorubicin[106]
      Ordered mesoporous carbon spherepH-magneticDoxorubicin[107]
      Ordered mesoporous carbon spheres coated with Fe3O4Magnetic-near infraredDoxorubicin[108]
      Porous carbon spheres coated with Au and Fe3O4Magnetic-near infraredDoxorubicin[109]
      Hollow porous carbon spherepH-redox potential-near infraredDoxorubicin[110]
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    Xiaokun CHENG, Yue ZHANG, Haijun Lü, Xinying LIU, Senlin HOU, Aibing CHEN. Porous Carbon Nanomaterials Based Tumor Targeting Drug Delivery System: a Review[J]. Journal of Inorganic Materials, 2021, 36(1): 9

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    Paper Information

    Category: REVIEW

    Received: May. 6, 2020

    Accepted: --

    Published Online: Jan. 21, 2021

    The Author Email: CHEN Aibing (chen_ab@163.com)

    DOI:10.15541/jim20200240

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