A CMOS full differential interface circuit with low noise and high linearity was presented for closed-loop capacitive micro-accelerometers. Based on switched-capacitor detection, the circuit was designed to improve its linearity by a 0.5 μm n-well CMOS process technology. The simulation result shows that the proposed two-path feedback structure provides a good system linearity of 0.01%. The optimized designed PID controller was added into the system,which decreases the stabilization error effectively, increases the system responding speed by 31%, and the linearity by 66.7%. With a ±5 V supply and a sampling frequency of 64 kHz, the circuit can offer the equivalent input noise in 8 μg·Hz-12, system sensitivity in 1.22 V/g, system linearity in 0.03%, and the work range in ±2 g. These results prove that this circuit is suitable for applications of high performance micro-accelerometers to seism detection, oil exploration,etc.