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Journal of Inorganic Materials, Volume. 35, Issue 12, 1365(2020)

Preparation of Mesoporous Organosilica-based Nanosystem for in vitro Synergistic Chemo- and Photothermal Therapy

Yulin ZENG1...2, Jiajie CHEN1,3, Zhengfang TIAN2, Min ZHU1,*, and Yufang ZHU23,* |Show fewer author(s)
Author Affiliations
  • 1School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
  • 2Hubei Key Laboratory of Processing and Application of Catalytic Materials, College of Chemical Engineering, Huanggang Normal University, Huanggang 438000, China
  • 3Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
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    AbstractGet PDF(in Chinese)
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    Figures & Tables(7)
    Characterization of MONs
    1. Characterization of MONs

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    (a) Zeta potential, (b) FT-IR spectra and (c) UV-Vis spectra of MONs, MONs-NH2, ICG/DOX-MONs and ICG/DOX-MONs@DNA20 nanoparticles
    2. (a) Zeta potential, (b) FT-IR spectra and (c) UV-Vis spectra of MONs, MONs-NH2, ICG/DOX-MONs and ICG/DOX-MONs@DNA20 nanoparticles

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    Photothermal heating curves of ICG/DOX- MONs@DNA20 suspension with different concentrations under NIR irradiation at 0.75 W/cm2, and (b) photothermal heating curves of 100 μg/mL ICG/DOX-MONs@DNA20 suspension under NIR irradiation at different power densities
    3. Photothermal heating curves of ICG/DOX- MONs@DNA20 suspension with different concentrations under NIR irradiation at 0.75 W/cm2, and (b) photothermal heating curves of 100 μg/mL ICG/DOX-MONs@DNA20 suspension under NIR irradiation at different power densities

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    Release profiles of (a) DOX and (b) ICG from ICG/DOX-MONs@DNA20 at 37 and 43 ℃, respectively, and (c) release profile of DOX and ICG from ICG/DOX-MONs@DNA20 at the alternating temperature between 37 and 43 ℃
    4. Release profiles of (a) DOX and (b) ICG from ICG/DOX-MONs@DNA20 at 37 and 43 ℃, respectively, and (c) release profile of DOX and ICG from ICG/DOX-MONs@DNA20 at the alternating temperature between 37 and 43 ℃

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    Cell viability of HeLa cells cultured with MONs with different concentrations for 24 and 48 h
    5. Cell viability of HeLa cells cultured with MONs with different concentrations for 24 and 48 h

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    Cell uptake of different nanoparticles after being cultured with HeLa cells for 3 h (blue: nuclei; red: DOX)
    6. Cell uptake of different nanoparticles after being cultured with HeLa cells for 3 h (blue: nuclei; red: DOX)

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    Cell viabilities of HeLa cells cultured with ICG/DOX-MONs and ICG/DOX-MONs@DNA20 with or without NIR irradiation
    7. Cell viabilities of HeLa cells cultured with ICG/DOX-MONs and ICG/DOX-MONs@DNA20 with or without NIR irradiation

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    Yulin ZENG, Jiajie CHEN, Zhengfang TIAN, Min ZHU, Yufang ZHU. Preparation of Mesoporous Organosilica-based Nanosystem for in vitro Synergistic Chemo- and Photothermal Therapy[J]. Journal of Inorganic Materials, 2020, 35(12): 1365

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    Paper Information

    Category: RESEARCH PAPER

    Received: Feb. 24, 2020

    Accepted: --

    Published Online: Mar. 10, 2021

    The Author Email: ZHU Min (mzhu@usst.edu.cn), ZHU Yufang (zjf2412@163.com)

    DOI:10.15541/jim20200091

    Topics

    laser devices and laser physics
    Lasers and Laser Optics
    Laser physics
    laser manufacturing
    Instrumentation, Measurement and Metrology