Huang

et al^[26]

大鼠

Rats

单次照射背部（50 Gy剂量），3~4周后形成溃疡，放射3周后局部注射ADSCs

Single irradiation of the back (50 Gy dose), ulcer formation after 3~4 weeks, local injection of ADSCs after 3 weeks of radiation.

ADSCs能增加创面的血供和肉芽率

ADSCs increase the blood supply and granulation rate of traumatic surfaces

Foubert

et al^[28]

小猪

Piggy

少量多次全身放射（总剂量1.2 Gy）+ 背部全层热烧伤，伤后3 d局部及静脉注射ADSCs

Small amount of multiple whole body radiation (total dose 1.2 Gy) + full back thermal burns, local and intravenous ADSCs injections 3 d after injury

ADSCs促进伤口的再上皮化，并增加血管密度和胶原蛋白

ADSCs promote wound re-epithelialization and increase vascular density and collagen

刘志燕等^[27]

Liu Z Y

et al

大鼠

Rats

单次照射大鼠左大腿内侧皮肤（90 Gy剂量），放射14 d出现溃疡，放射24 h后局部注射ADSCs

Single irradiation of rat left medial thigh skin (90 Gy dose), ulceration appeared 14 d after radiation, local injection of ADSCs 24 h after radiation

ADSCs促进血管生成和溃疡愈合

ADSCs promote angiogenesis and ulcer healing

Borrelli

et al^[33]

小鼠

Mice

少量多次放射小鼠头皮（总剂量30 Gy），放射后4周出现慢性纤维化效应，放射4周后局部注射CD74阳性的ADSCs

Small amount of multiple radiation to the scalp of mice (total dose 30 Gy), chronic fibrotic effect 4 weeks after radiation, local injection of CD74⁺ ADSCs 4 weeks after radiation

ADSCs具有明显的抗纤维化作用

ADSCs have a significant anti-fibrotic effect

Wu

et al^[34]

裸鼠

Naked rats

不同剂量照射裸鼠背部（最高剂量15 Gy×3），放射4周后创造皮肤伤口，并局部注射ADSCs

Irradiation of the back of nude mice at different doses (maximum dose 15 Gy×3), creation of skin wounds after 4 weeks of radiation, and local injection of ADSCs

ADSCs加速了伤口愈合并减少纤维化

ADSCs accelerate wound healing and reduce fibrosis

Khademi

et al^[48]

大鼠

Rats

单次照射臀部皮肤（30 Gy剂量），放射24 h后局部注射ADSCs

Single radiation of buttock skin (30 Gy dose), local injection of ADSCs 24 h after radiation

单独使用ADSCs并不能明显对减少辐射引起的皮肤损伤

The use of ADSCs alone does not significantly reduce radiation skin injury

Akita

et al^[29]

4名女性患者

4 female patients

几十年慢性骶尾骨、颈部等部位的放射性溃疡和组织严重纤维化，清创后人造真皮覆盖创面，并局部注射自体ADSCs

Decades of chronic sacrococcygeal and neck ulcers and severe fibrosis of the tissues, with artificial dermis covering the wound after debridement and local injection of autologous ADSCs

术后75 d创面可完全愈合，局部血液循环增加

Complete healing of the wound can be achieved 75 d after surgery, with increased local blood circulation

Chen

et al^[43]

1名53岁男性，口腔放疗后右上颌出现放射性骨坏死

A 53-year-old male with radiation osteonecrosis of the right maxilla after oral radiotherapy

牙槽清创后把PRF敷于患处、移植皮瓣后一期缝合

PRF was applied to the affected area after alveolar debridement, and the flap was grafted and sutured in one stage

术后3周内黏膜愈合，术后10个月随访X射线显示骨愈合良好

Mucosal healing within 3 weeks post-operatively and follow-up X-ray showed good bone healing at 10 months post-operatively

Maluf

et al^[44]

1名65岁女性，口腔放疗后右上颚后部出现放射性骨坏死

A 65-year-old female with radionecrosis of the right posterior maxilla after oral radiotherapy

清创后放置两片PRF膜

Placement of two PRF membranes after debridement

术后2周黏膜愈合，39个月的随访未见复发

Mucosal healing at 2 weeks post-operatively and no recurrence at 39 months follow-up

Palma

et al^[45]

23名头颈部肿瘤患者，60~70 Gy剂量放疗

23 patients with head and neck tumors treated with 60~70 Gy dose of radiotherapy

拔牙后PRF凝块填充牙窝

PRF clots filling of dental sockets after tooth extraction

临床评估180 d，两组在疼痛评分和放射性骨坏死发生率中无明显差异

No significant differences between the two groups in pain scores and incidence of radiation osteonecrosis at 180 d of clinical evaluation

Chen

et al^[50]

小猪

Minipig

单次照射右侧腮腺区域（20 Gy剂量），4个月后局部注射PRF联合ADSCs

Single irradiation of the right parotid area (20 Gy dose), followed by local injection of PRF combined with ADSCs after 4 months

6个月后软组织缺损区的血管密度显著增加，凋亡细胞减少

Significant increase in vascular density and decrease in apoptotic cells in the soft tissue defect area after 6 months

Wang

et al^[49]

小鼠

Mice

单次照射小鼠头部和颈部（18 Gy剂量），12周后局部注射ADSCs和PRF析出液

Single irradiation of the head and neck of mice (18 Gy dose), followed by local injection of ADSCs and PRF extract after 12 weeks

12周后联合组的唾液腺腺泡细胞损伤和萎缩更少，淀粉酶水平与微血管密度增加更明显

The combined group had less salivary gland follicle cell damage and atrophy and a more pronounced increase in amylase levels and microvessel density after 12 weeks

Lawb

et al^[51]

1名69岁男性

A 69-year-old male

右下颌骨放射性骨坏死，切除坏死下颌骨后放置两片PRF膜+自体脂肪移植

Radiation osteonecrosis of the right mandible, removal of necrotic mandible and placement of two PRF membranes + autologous fat graft

3周后黏膜完全愈合，2个月后创面区血液灌注明显改善

Complete mucosal healing after 3 weeks and significant improvement in blood perfusion in the trabecular area after 2 months