A high frame rate imaging technology based on asynchronous timing drive and Binning technology has been applied on frame transfer CCD camera successfully. The reason why smear noise occurs in image acquisition process has been analyzed theoretically and a complete set of numerical analytic algorithm for smear correction has been carried out to restraint the smear generated in the imaging of this CCD camera, according to its continuous imaging principle. The algorithm has fully taken the effects of consecutive frame exposures and changing intensity on smear into account and then amended them. Experimental verification has been conducted in asynchronous Binning camera. Results indicate that the camera can get 4 continuous images at a frame rate of 40 000 frames per second. The algorithm has effectively eliminated the smear noise of all images, making contribution to the remarkable decrease of the gradation variance in smear area and the improvement of asynchronous Binning CCD cameras imaging quality. The smear correction algorithm is applicable to continuous imaging of high frame rate camera.