Journal of Inorganic Materials, Volume. 37, Issue 11, 1203(2022)

Copper-incorporated Calcium Silicate Nanorods Composite Hydrogels for Tumor Therapy and Skin Wound Healing

Aijun WU1...2, Min ZHU1,* and Yufang ZHU2,* |Show fewer author(s)
Author Affiliations
  • 11. School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China
  • 22. State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
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    Figures & Tables(13)
    XRD patterns of Cu-CS powders prepared by molten salt method with (a) different amounts of copper salt and (b) different temperatures
    SEM images of (a) CSH, (b) CS and (c) 3Cu-CS powders
    (a) TEM image, (b) EDS spectrum and (c) elemental mapping of 3Cu-CS nanorods
    (a) Cu2p XPS spectrum of 3Cu-CS nanorods, Cu amounts of Cu-CS nanorods prepared with (b) different copper salt additions and (c) different temperatures by ICP-AES method, respectively. *p< 0.05, **p< 0.01, ***p< 0.001
    Chemodynamic effects of Cu-CS nanorods
    SEM images of the surfaces and cross sections for (a, d1, d2) SA, (b, e1, e2) 20%-CS/SA and (c, f1, f2) 20%-Cu-CS/SA hydrogels
    Release behaviors of (a) Ca, (b) Si and (c) Cu ions from SA, 20%-CS/SA and 20%-Cu-CS/SA hydrogels in Tris-HCl buffer
    Chemodynamic effects of Cu-CS/SA hydrogels
    Cell viabilities of HUVECs and HDFs after 24 h incubation with hydrogels incorporated with different contents of Cu-CS nanorods
    Fluorescence images of B16F10 cells after different treatments for observing intracellular ROS
    Cell viability of B16F10 cells after different treatments
    Cell proliferations of (a) HUVECs and (b) HDFs cultured with different hydrogels
    (a, b) Cell migration images and (c, d) corresponding migration rates of (a, c) HUVECs and (b, d) HDFs after cultured with SA, 20%-CS/SA and 20%-Cu-CS/SA hydrogels for 24 h, respectively ( **: p< 0.01)
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    Aijun WU, Min ZHU, Yufang ZHU. Copper-incorporated Calcium Silicate Nanorods Composite Hydrogels for Tumor Therapy and Skin Wound Healing[J]. Journal of Inorganic Materials, 2022, 37(11): 1203

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    Paper Information

    Category: RESEARCH ARTICLE

    Received: Mar. 21, 2022

    Accepted: --

    Published Online: Jan. 12, 2023

    The Author Email: ZHU Min (mzhu@usst.edu.cn), ZHU Yufang (zjf2412@163.com)

    DOI:10.15541/jim20220164

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