Infrared and Laser Engineering, Volume. 53, Issue 12, 20240356(2024)
Modeling and simulation of whole-link SNR of fluorescence endoscope
Figures & Tables(12)
Fig. 2. Flow chart of establishing whole-link SNR model for fluorescence endoscope
Fig. 4. (a) 3D transmission distribution of incident photon packets; (b) 3D transmission distribution of fluorescent photon packets
Fig. 5. (a) Pseudo-color schematic of fluorescence irradiance of a tumor on the surface of a tissue body simulated using the described method; (b) Pseudo-color schematic of fluorescence irradiance of a tumor on the surface of a tissue body simulated by TracePro
Fig. 6. The transmission and distribution of incident Gaussian beam in tissue
Fig. 7. Fluorescence average irradiance distribution of tumors with different sizes in different depths of tissues. (a) Tumors of 1 mm radius; (b) Tumors of 2 mm radius; (c) Tumors of 3 mm radius; (d) Tumors of 4 mm radius; (d) Tumors of 5 mm radius
Fig. 8. (a) Fluorescence irradiance of tumors with different depths and sizes on tissue surface; (b) Systematic signal-to-noise ratio of tumors of different depths and sizes
Table 1. Optical parameters of Gaussian light source
View tableView in ArticleTable 1. Optical parameters of Gaussian light source
Parameter Value Total power/W 2 x, y direction equal number of divisions 1200 Waist radius/mm 0.0002571 Semi-angle/(°) 45 Wavelength/nm 808 Incident light energy weighting coefficient 0.85
Table 2. The parameters of biological tissue and fluorescence molecular probe
View tableView in ArticleTable 2. The parameters of biological tissue and fluorescence molecular probe
Parameter Value n 1.368 $ \mu_{{\mathrm{a}}} $ 0.32 $ \mu_{{\mathrm{s}}} $ 41.4 g 0.95 $ \eta $ 0.8 Molar maximum extinction coefficient /liter·mole·cm−1 295000 Molar concentration/mole·liter−1 0.5 Fluorescence energy weighting coefficient 0.95
Table 3. Optical imaging system parameters
View tableView in ArticleTable 3. Optical imaging system parameters
Parameter Value Pupil entry area/mm2 0.19 Transmittance 96.07％ Integral time/ms 23 Mean operating wavelength/nm 830 Detector quantum yield 50％ Readout noise/e− 30 Dark current noise/e− 50 The exit angle of fluorophore on tissue surface/(°) 0 Air layer transmittance 99.8％ Angle between the tissue and the detector entry pupil/(°) 0 Number of pixels occupied by the image 1.48×105
Table 4. Mean irradiance of fluorescence on the surface of the tissue when tumors of different sizes are located at different depths within the tissue
View tableView in ArticleTable 4. Mean irradiance of fluorescence on the surface of the tissue when tumors of different sizes are located at different depths within the tissue
Irradiance/W·m−2 r=0.5 mm r=1 mm r=1.5 mm r=2 mm r=2.5 mm r=3 mm r=3.5 mm r=4 mm r=4.5 mm r=5 mm z=35 mm 2.4×10−19 9.4×10−19 0.023 0.091 0.56 0.88 1.94 8.15 16.30 35.28 z=36 mm 3.3×10−42 1.3×10−35 4.3×10−3 6.6×10−3 0.10 0.49 0.91 2.4 4.32 8.91 z=37 mm 0 6.8×10−25 5.9×10−16 4.1×10−7 6.7×10−6 0.036 0.21 0.56 1.14 1.77 z=38 mm 0 0 1.4×10−19 1.3×10−13 1.3×10−19 0.014 1.4×10−5 0.21 0.37 0.83 z=39 mm 0 0 1.2×10−35 0 7.2×10−16 0.004 2.9×10−6 0.037 0.11 0.27 z=40 mm 0 0 0 0 2.5×10−48 2.3×10−17 2.2×10−11 3.8×10−11 2.7×10−4 0.076 z=41 mm 0 0 0 0 0 2.3×10−24 6.4×10−15 1.3×10−13 2.5×10−10 1.8×10−13 z=42 mm 0 0 0 0 0 2.5×10−47 0 8.4×10−30 1.5×10−29 3.4×10−15 z=43 mm 0 0 0 0 0 0 0 0 0 1.8×10−19 z=44 mm 0 0 0 0 0 0 0 0 0 8.4×10−30 z=45 mm 0 0 0 0 0 0 0 0 0 0
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Mingjie QIU, Xiangxiang MENG, Han SHANG. Modeling and simulation of whole-link SNR of fluorescence endoscope[J]. Infrared and Laser Engineering, 2024, 53(12): 20240356
Paper Information
Category: 光电测量
Received: Aug. 7, 2024
Accepted: --
Published Online: Jan. 16, 2025
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