Acta Physica Sinica, Volume. 69, Issue 16, 163301-1(2020)

Electrical characteristics of cells with electrical impedance spectroscopy

Jia-Feng Yao... Jian-Fen Wan, Lu Yang, Kai Liu*, Bai Chen and Hong-Tao Wu |Show fewer author(s)
Author Affiliations
  • College of Electrical and Mechanical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China
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    Figures & Tables(7)
    Simulation model (a)−(c) Model of cell; (d), (e) model of simulation area.
    Simulation results of different cells and Cole-Cole Plot: (a) Simulation results of different frequencies of different cells; (b) Cole-Cole Plot of different cells.
    Simulation results of no-nuclear cells with or without membrane: (a) Simulation results of non-nucleated cells with different frequencies; (b) the Cole-Cole Plot corresponding to the simulation results.
    Simulation results of cells with different nuclear radius: (a) Simulation results of cells at different frequencies; (b), (c) Cole-Cole Plot of different nuclear radius.
    Experimental set-up.
    Experiment: (a) Object and model of dead and alive yeast; (b) Cole-Cole Plot of 20% dead and alive yeast.
    • Table 1.

      Simulation parameters of normal and malignant (farage) onsillar B-cells[19].

      正常B细胞及病变B细胞的仿真参数

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      Table 1.

      Simulation parameters of normal and malignant (farage) onsillar B-cells[19].

      正常B细胞及病变B细胞的仿真参数

      参数正常细胞癌细胞
      导电率σ/S·m–1环境0.60.6
      细胞膜5.6 × 10–59.1 × 10–6
      细胞质1.310.48
      核膜1.11 × 10–24.4 × 10–3
      核质2.041.07
      相对介电常数环境8080
      细胞膜12.89.8
      细胞质6060
      核膜10660.3
      核质120120
      几何参数/μm仿真区域(L × L) 20 × 2020 × 20
      电极 $ (l) $2 × 42 × 4
      细胞半径(R1) 3.35.2
      细胞核半径(R2) 2.84.4
      细胞膜厚(d1) 0.0070.007
      核膜厚(d2) 0.040.04
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    Jia-Feng Yao, Jian-Fen Wan, Lu Yang, Kai Liu, Bai Chen, Hong-Tao Wu. Electrical characteristics of cells with electrical impedance spectroscopy[J]. Acta Physica Sinica, 2020, 69(16): 163301-1

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    Paper Information

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    Received: Apr. 24, 2020

    Accepted: --

    Published Online: Jan. 4, 2021

    The Author Email:

    DOI:10.7498/aps.69.20200601

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