Acta Optica Sinica, Volume. 44, Issue 1, 0106015(2024)

Advances in Distributed Fiber Optic Biochemical Sensing Technology

Peidong Hua, Zhenyang Ding*, Kun Liu, Haohan Guo, Teng Zhang, Sheng Li, Ji Liu, Junfeng Jiang, and Tiegen Liu
Author Affiliations
  • School of Precision Instrument and Opto-Electronics Engineering, Key Laboratory of Opto-Electronics Information Technology, Ministry of Education, Tianjin Optical Fiber Sensing Engineering Center, Tianjin University, Tianjin 300072, China
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    Figures & Tables(13)
    Experimental setup for gas sensing network based on DWDM and TDM[40]
    Output spectra via DWDMs and scanned spectra via FP filter in channels 1-4 when HC-PCF is filled with C2H2 of 0.1 volume fraction[40]. (a) Channel 1; (b) channel 2; (c) channel 3; (d) channel 4
    Measured response of sensor to variations of ambient RI[55]. Reconstructed interferograms for (a) MI formed between R0 and R1 and (c) MI formed between R0 and R2 for different settings of ambient RI; (b) resonant magnitude at ∼3.278 GHz of sensing reflector R1 as a function of ambient RI; (d) resonant magnitude at ∼3.196 GHz of sensing reflector R2 as a function of ambient RI
    Schematic illustration of optical setup of ArFAB as well as direct (label-free) and sandwich (plasmonic labeled) immunoassays over surface of U-FOS probes[66]
    Eight channel U-FOS probe sensing experiment[66]. (a) Real-time binding kinetics obtained due to AuNP labels interacting with antigen on U-FOS probes at 280 nm; (b) dose-response curve obtained with ArFAB device for different known concentrations of HIgG [line at the bottom shows the control response from the probes subjected to 0 ng/mL HIgG (n≥3)]
    Distributed hydrogen sensing with stimulated Raman scattering[71]. (a) Schematic of butt coupling of fiber I with fiber II; (b) schematic of sensing fiber for distributed hydrogen detection over 200-m-long sensing distance, and measured Raman gain trace measured with 18 ns pump pulse
    Experimental setup for distributed RI sensor using tapered fibers in OFDR[74] (TLS is tunable laser source, FRM is Faraday rotating mirror, PC is polarization controller, BPD is balanced photoelectric detector, DAQ is data acquisition card, FUT is fiber under test, and tapered fiber is immersed in a tank with glycerol solution)
    Distributed RI sensing under different RI[74]. (a) Spectral shift of the Rayleigh scattering in the tapered fiber as a function of distance at different RI; (b) fitting curve of optical frequency as a function of RI
    Distance-time distribution of RI variation in diffusion of glycerol solution[73] (glycerol diffused from one side to the other side in sink over time, and RI variation was detected from the one side to the other side of tapered fiber over time)
    Experiment of distributed localization and biosensing[85]. (a) Schematic diagram of container used in localization experiment of biochemical substances in proposed distributed biosensor; (b) RBS shifts in tapered fiber as a function of distance at different time after adding anti-human IgG to the slot in the container (dotted line marks change of RBS shift at localization point over time); (c) RBS shift of entire tapered region at a time interval of 270 s (position of peak 90.44 mm is location point of slot in container we designed)
    • Table 1. Comparison of RI sensitivity of various quasi-distributed optical fiber sensors

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      Table 1. Comparison of RI sensitivity of various quasi-distributed optical fiber sensors

      Sensor typeMaximum RI sensitivity /(nm/RIU)Sensing rangeRef. No
      MFPIs151.619 mm51
      SPR2002 mm45
      Fresnel-reflection based fiber sensor304250 m47
      TFBG-SPR5001 cm48
      Fiber tip6222 cm55
      FPI1200100 μm52
      Side-polished SPR179510 mm53
      Eccentric-core SPR47381 mm49
      Multi-core SPR53819 mm50
    • Table 2. Position for various quasi-distributed optical fiber biochemical sensing

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      Table 2. Position for various quasi-distributed optical fiber biochemical sensing

      Sensing positionRef. No
      Practical sensor/actuator system for chemical leakage56],[58],[60],[61
      Monitoring of toxic groundwater or soil chemical compounds57
      DNA59
      Cancer biomarkers in the blood62],[65],[66
      Blood thrombin in the blood64
    • Table 3. Comparison of RI sensitivity of various distributed optical fiber sensors

      View table

      Table 3. Comparison of RI sensitivity of various distributed optical fiber sensors

      Sensor typeRI sensitivity /(nm/RIU)Sensing range /mmSpatial resolution /mmRef. No
      Etched MgO nanoparticle-doped SMF1.5312178
      Etched Ge-Doped SMF19.181005.2579
      U-bending fiber20.7411.311.377
      U-bending fiber39.084480
      Etched multi-core fiber471905.381
      Tapered fiber60214.2576
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    Peidong Hua, Zhenyang Ding, Kun Liu, Haohan Guo, Teng Zhang, Sheng Li, Ji Liu, Junfeng Jiang, Tiegen Liu. Advances in Distributed Fiber Optic Biochemical Sensing Technology[J]. Acta Optica Sinica, 2024, 44(1): 0106015

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    Paper Information

    Category: Fiber Optics and Optical Communications

    Received: Aug. 14, 2023

    Accepted: Sep. 28, 2023

    Published Online: Jan. 12, 2024

    The Author Email: Ding Zhenyang (zyding@tju.edu.cn)

    DOI:10.3788/AOS231397

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