Lead halide perovskites have started a new era for solar cells. However, the toxicity of lead poses challenge for their practical applications. Replacing lead with tin provides a feasible way to reduce the toxicity of lead perovskites and can further promote the applications of perovskites. Due to their reduced toxicity with advantageous optical and electronic properties compared to their lead counterparts, tin (II) perovskites (TiPes) have attracted significant interests in recent years, not only for pursuing high-performance solar cells, but also in other application fields. This review aims at providing a comprehensive overview of recent advances in TiPes, covering fundamental crystal structure, optoelectronic properties, fabrication methods, and applications. A detailed comparison with lead perovskites is included, emphasizing TiPes’ unique strengths while presenting their application challenges. Finally, potential solutions to the challenges are proposed, along with a vision for their future development and potential.