Lycium ruthenicum Murray (Solanaceae Lycium) is rich in various mineral elements, which have extremely important biological effects on the growth and development of human beings. Lycium ruthenicum Murray is a homologous substance used in medicine and food. It is necessary to analyze its dissolution characteristics and correlation analysis to understand its nutritional value and seek healthy diet guidance and further utilization. In this study, Lycium ruthenicum Murray was pretreated using the microwave digestion method and the pure water extraction method. Digestion solutions were prepared using a microwave digestion apparatus using nitric acid and hydrogen peroxide as digestion acid. Soaking solutions were prepared with pure water at different temperatures. Contents of mineral elements, including K, Na, Ca, Mg, Zn, Fe, Mn, Cu, Li and Sr, were determined by inductively coupled plasma optical emission spectrometry (ICP-OES), and the dissolution characteristics and correlation analysis of mineral elements were studied then. Under the optimal working conditions of microwave digestion and the spectrometer, a good linear relationship (r>0. 999 5), lower detection limit (LOD<0. 01 mg·L-1), and high accuracy and precision were obtained. Recovery rates of the elements were between 97. 2% and 101. 8%, with a relative standard deviation (RSD) lower than 1. 99%. The results showed that beneficial mineral elements are rich in Lycium ruthenicum Murray. It is high in K, followed by Na, Ca and Mg, then Fe, Li and Sr, and lower in Mn, Zn and Cu. The K/Na value in Lycium ruthenicum Murray is greater than 8. Moreover, it proved that Lycium ruthenicum Murray is a typical food with high potassium and low sodium. Ca, Mg, Fe, Zn, Li, Sr, Mn and Cu are also important components of various enzymes, hormones and vitamins in the human body. Lycium ruthenicum Murray is certified as an ideal food. Li content is not obviously correlated with Ca, Zn, and Fe content in the soaking solutions. Mg content is not obviously correlated with Zn content. Besides, other correlations between one content and another were significantly positive or extremely significant positive. It showed that there was no obvious antagonism in the mineral elements. The dissolved amount of minerals in the soaking solutions increased with the brewing time and brewing temperature. The extraction temperature of 40℃ and boiling water, and extraction time of 5, 10 and 20 min were selected to study the influence of extraction temperature and time on the dissolution rate. K, Na and Zn have the highest dissolution rates among the then elements. Although contents of Ca, Mg, Sr, Mn and Cu vary greatly from each other, the dissolution rates are similar, which may be due to the same valence states and the similar extraction efficiency. The dissolution rate of Li is greatly affected by the extraction temperature, and the dissolution rate in boiling water is 1. 5~2 times that in 40 ℃ water with different extraction duration. The content of Fe in trace elements is the highest, but the dissolution rate is the lowest, mainly because Fe is combined with proteins and is difficult to extract. The study could provide reliable evidence for a healthy diet and the further utilization of Lycium ruthenicum Murray.