In order to investigate the effect of heat activated oil shale semi-coke on the durability of concrete, and promote the application of cement-oil shale semi-coke concrete, the effects of different activation and calcination temperatures (300, 400, 500 and 600 ℃) and different content (0%, 5%, 10%, 15%, 20% and 25%, mass fraction) of oil shale semi-coke on the durability of concrete were investigated using the concrete carbonation test, chloride ion penetration resistance test and frost resistance test. The nuclear magnetic resonance (NMR) test was used to analyze the pore size distribution and porosity of concrete, and the influence mechanism of oil shale semi-coke on the durability of concrete was revealed from the pore size distribution characteristics. The results show that compared with the activation and calcination temperature of oil shale semi-coke, the effect of content on the concrete durability is more significant. The incorporation of oil shale semi-coke reduces the carbonation resistance of concrete, but it still meets the requirements of the standard design value at 25% content. And the carbonation depth is far less than 20 mm. The chloride ion penetration resistance also decreases with the incorporation of oil shale semi-coke, and it is still in the low permeability range when the content is not higher than 25%. 5 kinds of oil shale semi-coke content of concrete can meet the requirements of 150 times freeze-thaw cycles, overall having good durability. In addition, the incorporation of oil shale semi-coke significantly changes the pore size distribution and pore number inside concrete, thus affecting the durability of concrete to varying degrees.