Journal of Innovative Optical Health Sciences, Volume. 16, Issue 6, 2340006(2023)

Semantic segmentation of pyramidal neuron skeletons using geometric deep learning

Lanlan Li1... Jing Qi1, Yi Geng1 and Jingpeng Wu2,* |Show fewer author(s)
Author Affiliations
  • 1Fujian Key Lab for Intelligent Processing and Wireless Transmission of Media Information, College of Physics and Information Engineering, Fuzhou University, Fuzhou, Fujian 350116, P. R. China
  • 2Center for Computational Neuroscience, Flatiron Institute, New York 10010, USA
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    Neurons can be abstractly represented as skeletons due to the filament nature of neurites. With the rapid development of imaging and image analysis techniques, an increasing amount of neuron skeleton data is being produced. In some scientific studies, it is necessary to dissect the axons and dendrites, which is typically done manually and is both tedious and time-consuming. To automate this process, we have developed a method that relies solely on neuronal skeletons using Geometric Deep Learning (GDL). We demonstrate the effectiveness of this method using pyramidal neurons in mammalian brains, and the results are promising for its application in neuroscience studies.

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    Lanlan Li, Jing Qi, Yi Geng, Jingpeng Wu. Semantic segmentation of pyramidal neuron skeletons using geometric deep learning[J]. Journal of Innovative Optical Health Sciences, 2023, 16(6): 2340006

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    Paper Information

    Category: Research Articles

    Received: Apr. 14, 2023

    Accepted: Jul. 18, 2023

    Published Online: Dec. 23, 2023

    The Author Email: Wu Jingpeng (jwu@flatironinstitute.org)

    DOI:10.1142/S1793545823400060

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