Based on the multidisciplinary nature of biomedical engineering, a comprehensive experimental teaching design is investigated. Using a project-based learning approach, a variety of experiments are conducted. A comprehensive experiment design is introduced on the topic of “The application of conductive hydrogel materials in flexible electronics and the human body”, including the preparation of conductive hydrogel, the evaluation of material performance, the detection of electrical signals on flexible electrode surfaces, and physiological signals analysis using Python. Furthemore, a “medical materials+” teaching system is developed, which integrates expertise in electronics, computer information processing, and materials science. The experimental arrangement breaks through the limitations of chapter experiments and effectively increases the depth and breadth of professional instruction by reflecting the intersection and integration of biomedical engineering disciplines.