The molar entropy (△S） and molar enthalpy (△H） for the denaturation event that triggers cutaneous erythema was determined to be △S = 190 J/(mole K) and △H = 146.9 × 10³ J/mole. The experiment involved placing heated water against the skin of the forearm, for a range of temperatures and exposure times. Exposing the skin to 45℃ for 22 s was at the threshold for producing erythema, which was similar to the threshold for a slight degree of pain.