Based on the analysis of the optical characteristic of Nd∶YAG ceramic, a laser diode (LD) pumped high-efficiency high-repetition-rate acousto-optic (A-O) Q-switched miniature Nd∶YAG ceramic laser was developed. Near infrared laser at 1064 nm was obtained with LD end-pumping Nd∶YAG ceramic. Fused silica was adopted as A-O Q-switch crystal and the Q-switch repetition rate is adjustable from 1 Hz to 115 kHz. With a 2W LD pumping, stable operation with pulse width of 16.4 ns peak power of 2.46 kW and energy per pulse of 40.5 μJ, was achieved. At 110 kHz repetition rate, 495 mW average output power of 1064 nm was obtained, corresponding to total optical-to-optical conversion efficiency being as high as 24.75%. The experimental study about the influence of repetition rate and pumping power on the performance of A-O Q-switched pulse laser was emphasized, and the experiment results were analyzed and discussed.