The deformable mirror fitting ability of wavefront aberration is analyzed through influence function matrix. A wavefront control algorithm which filters the influence of high-order mode aberration is proposed. It makes up the deficiency of the steepest descent method which cannot optimize the correction process by selecting aberration mode,and improves the correction ability of deformable mirror. Wavefront distortion of a human eye is used in the experiment as the incident wavefront. The results show that the root-mean-square (RMS) value of wavefront aberration can decline to the diffraction limit after six iterations and the frequency of the closed-loop calibration system is 15 Hz. This indicates that micromachined membrane deformable mirror adaptive optics system based on the control algorithm can meet the demand of real-time human eye aberration correction. It offers an appropriate algorithm for small and low-cost system of human eye wavefront aberration correction.