The high strength cement concrete (HSCC) has excellent mechanical properties and durability, and it is one of the most commonly used construction materials in the key major civil engineering projects. Realizing the pressure sensitivity of HSCC can automatically monitor and test the service capacity of structures, and improve the safety and reliability of buildings. In this paper, HSCC with a 28 d compressive strength of more than 80 MPa was constructed by using micro steel fibers and nano-carbon black (NCB). The effect of NCB content on the mechanical properties and pressure sensitivity of HSCC was studied. The results show that the mechanical properties of HSCC are affected by NCB. The compressive and flexural strength of HSCC with an optimal NCB content of 0.05% of cement mass fraction are about 21.0%~33.0% and 9.6%~33.8% higher than that of the control one, respectively. NCB significantly improves the pressure sensitity of HSCC. The higher the content is, the more significant the pressure sensitivity is, the smaller the noise is, and the better the stability is. The force-electric signal relation follows exponential function relationship and the fitting degree is 0.923. The effect of NCB on the pressure sensitivity of HSCC conforms to the seepage principle, and its seepage threshold is about 0.1%, and the average sensitivity coefficient is increased by 5.0 times.