Acta Photonica Sinica, Volume. 48, Issue 12, 1206001(2019)
Biosensor Based on Cladding-etched 81° Tilted Fiber Grating Coated with Graphene Oxide
In order to improve the sensitivity and limit of detection of 81° tilted fiber grating, bovine serum albumin immunosensor based on graphene oxide modified cladding-etched 81° tilted fiber grating was proposed, the principle and sensing properties of the sensor were analyzed. Refractive index sensitivity of 81° tilted fiber grating was improved by etching with hydrofluoric acid. Then the etched 81° tilted fiber grating was coated with graphene oxide, and bovine serum albumin monoclonal antibody were modified on the surface of 81° tilted fiber grating for the specific detection of bovine serum albumin. Experimental results show that the detection range of the immunosensor is 0.15~15 nmol/L, limit of detection ~0.165 nmol/L, and the sensitivity in its linear response region is ~182 pm/(nmol·L-1). Although the detection range decrease, the sensitivity is ~5.3 times of that of the un-etched graphene oxide coated 81° tilted fiber grating, and the limit of detection is also improved.
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Ya-jie WANG, Bin-bin LUO, Sheng-hui SHI, Shang-hai JIANG, De-cao WU, Sheng-xi WU, You-ming LU, Tao-jiang WU, Ming-fu ZHAO. Biosensor Based on Cladding-etched 81° Tilted Fiber Grating Coated with Graphene Oxide[J]. Acta Photonica Sinica, 2019, 48(12): 1206001
Received: Jun. 10, 2019
Accepted: Jul. 23, 2019
Published Online: Mar. 17, 2020
The Author Email: LUO Bin-bin (luobinbin@cqut.edu.cn)