Journal of Innovative Optical Health Sciences, Volume. 9, Issue 2, 1650005(2016)

Change of photosensitizer fluorescence at its diffusion in viscous liquid flow

Valeriya S. Maryakhina* and Vyacheslav V. Gun'kov
Author Affiliations
  • Orenburg State University 13 Pobedy st., Orenburg 460018, Russia
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    In this paper, the mathematical model of distribution of the injected compound in biological liquid flow has been described. It is considered that biological liquid contains a few phases such as water, peptides and cells. The injected compound (for example, photosensitizer) can interact with peptides and cells. At the time, viscosity of the biological liquid depends on pathology present in organism. The obtained distribution of the compound connects on changes of its fluorescence spectra which are registered during fluorescent diagnostics of tumors. It is obtained that the curves do not have monotonic nature. There is a sharp curves decline in the first few seconds after injection. Intensivity of curves rises after decreasing. It is especially pronounced for wavelength 590 nm and 580 nm (near the \transparency window" of biological tissues). Time of in- flection point shifts from 8.4 s to 6.9 s for longer wavelength. However, difference between curves is little for different viscosity means of the biological liquid. Thus, additional pathology present in organism does not impact to the results of in vivo biomedical investigations.

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    Valeriya S. Maryakhina, Vyacheslav V. Gun'kov. Change of photosensitizer fluorescence at its diffusion in viscous liquid flow[J]. Journal of Innovative Optical Health Sciences, 2016, 9(2): 1650005

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    Paper Information

    Received: May. 17, 2015

    Accepted: Jun. 29, 2015

    Published Online: Dec. 27, 2018

    The Author Email: Maryakhina Valeriya S. (v.s.maryakhina@gmail.com)

    DOI:10.1142/s179354581650005x

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