To improve the dynamic range of imaging equipment when detecting targets with great intensity differences simultaneously, a pixel-level adjustable telescope based on Digital Micromirror Device (DMD) is designed. The system has an intermediate image plane on DMD. First of all, the micromirrors of the DMD are on and one image of the target is obtained and divided into several little zones according to mean gray level and locality dynamic, and parameters such as time of exposure of each zone are set up. It is effective based on the parameters to modulate the corresponding micromirror’s on-off statement and time, which will improve the dynamic range of the system. The dynamic range of the designed telescope with effective focal length of 223 mm, F-number of 5, field of 3° and wavelength range from 480 nm to 760 nm, can be up to 140 dB. The design results show that, on the image plane of DMD, the modulation transfer functions of each field is greater than 0.70 at Nyquist frequency and the distortion is close to 0, and on the image plane of detector, the modulation transfer function of each field is greater than 0.55 at Nyquist frequency and the distortion is less than 2%.