To solve the problems of high noise and low pixel of traditional industrial X-ray flat-panel detector, a 3 072×3 072-pixel X-ray flat-panel detector signal acquisition system has been designed by using an amorphous silicon thin-film transistor (TFT) flat-panel, a mature analog-to-digital converter(ADC) chip of ADI, a driver module of Himax, and a field-programmable gate array (FPGA). This project takes ZYNQ7020 as the core processor for circuit design, and realizes the comprehensive layout and wiring, simulation and debugging of FPGA. The system, under the action of the control signal of FPGA, implements the driver module to control the switch of the TFT, the analogue front-end (AFE) to collect the charge signal of 3 072 channels in parallel at the same time, and then the data is converted into the signal by denoising, amplifying, and AD conversion in a Low Voltage Differential signal (LVDS) interface serial output, and finally successfully obtained the acquisition signal, verified the function of the system, which can provide a design idea for the study of X-ray detectors.