Based on the analysis of the imaging process of optoelectronic imaging anti-ship missile, an image registration algorithm based on sensor parameters and region of interest (RDI) is proposed. Originally the distortion between infrared and visible images is affine. Firstly, by adjusting sensor parameters, the scaling change between images is eliminated and the affine transform is simplified into rigid transform. Then the ROI is got by locating the horizontal region, and the center of the target′s contour is computed by morphological edge detection and chosen as control point, which is used to eliminate the translational change between images and achieve complete alignment. Finally, the registration effect is assessed by using the rule of root mean square error. The simulation experiments convince that the algorithm is accurate and fast, and can meet the precision requirement for target recognition, providing a good way for solving the difficult registration problem of small target images with different sensors.