The influencing factors of the viewing comfort of the stereo images is the key issue in the stereo imaging technology field. Combined with the characteristics of the visual attention mechanism, the influence of saturation factor on visual comfort of stereo image is quantitatively studied in this paper. Firstly, the stereo salient degree map is obtained, after that the fuzzy membership principle and the mask processor are put on it to get the final salient stereo image, and the eye tracker is used to verify the correctness of the salient area of the obtained stereo image. Then the subjective experiments are carried out with improved gradual approximation method, and the matching map and difference map of the comfortable saturation of the salient stereo image are obtained through a large number of experimental data. The experimental results show that the maximum average difference value of the comfortable saturation of the binocular view is 0.29. The verifying experiment shows the comfortable saturation ranges with the proposed method have a good universality. This work not only provides a basis for the study of stereo image comfort, but also provides technical standards for the making of stereo content.