This paper reviews the history of the optoelectric devices applied to biomedical sciences in 20th century. It describes history of Vacuum tubes and Spectroscopies with the author’s personal experiences, especially doublebeam spectroscopy. Further, the present developments of Near Infra Red (NIR) devices are described in translational biomedical applications. It includes particulary micro optoelectronics developments and present status of NIR breast cancer detection. Lastly, intrinsic molecular biomarkers are discussed especially NIR measurements of angiogenensis, hypermetabolism and heat production for cancer detection.