Journal of Innovative Optical Health Sciences, Volume. 17, Issue 3, 2450002(2024)
Reduction of photodynamic damage of blood vessels in the protected region by (–)-epigallocatechin gallate
Photodynamic therapy (PDT) has been increasingly used in the clinical treatment of neoplastic, inflammatory and infectious skin diseases. However, the generation of reactive oxygen species (ROS) may induce undesired side effects in normal tissue surrounding the treatment lesion, which is a big challenge for the clinical application of PDT. To date, (–)-Epigallocatechin gallate (EGCG) has been widely proposed as an antiangiogenic and antitumor agent for the protection of normal tissue from ROS-mediated oxidative damage. This study evaluates the regulation ability of EGCG for photodynamic damage of blood vessels during hematoporphyrin monomethyl ether (Hemoporfin)-mediated PDT. The quenching rate constants of EGCG for the triplet-state Hemoporfin and photosensitized 1O2 generation are determined to be
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Tianlong Chen, Yi Shen, Li Lin, Huiyun Lin, Xuejiao Song, Defu Chen, Buhong Li. Reduction of photodynamic damage of blood vessels in the protected region by (–)-epigallocatechin gallate[J]. Journal of Innovative Optical Health Sciences, 2024, 17(3): 2450002
Category: Research Articles
Received: Oct. 1, 2023
Accepted: Jan. 14, 2024
Published Online: Apr. 26, 2024
The Author Email: Shen Yi (yishen@fjnu.edu.cn), Li Buhong (bhli@hainanu.edu.cn)