The research on the dynamic response of steel tower frame structure on reef sand foundation under explosion loading has important practical significance for our national defense and reef engineering construction.In this work,the acceleration dynamic response signals of steel tower frame structure for different reef sand foundation types,explosive charges,distances to blasting center and other working conditions were tested through model tests.Combined with dimensional formula and π theorem,the acceleration dynamic response calculation formula of the steel tower frame structure model is obtained.Then this formula is fitted by using the data collected from the tests to determine the related parameters.Finally,the acceleration dynamic response empirical formula of steel tower frame model on reef sand foundation is obtained.