A 3D-SPECK in conjunction with ROI is applied to compress hyperspectral image sequences produced by the LASIS system.Firstly,the hyperspectral image sequences are decomposed with three-dimensional asymmetric DWT.Secondly,the Zero Block Tree is defined as codeunits.Then different coding rates are distributed to each codeunits in different regions (ROI or BG) to protect the hyperspectral information.Finally,the adapted 3D-SPECK algorithm is used to encode the codeunits individually.The numerical experiment results show that the PNSR is more than 40dB at 8:1 compression rate,and achieve the efficient protection of hyperspectral information.It is of lower computational complexity and higher real time performance,which can satisfy LASIS′s compression requirements.