Frontiers of Optoelectronics, Volume. 13, Issue 4, -1(2020)
Super-resolution imaging of the dynamic cleavage of intercellular tunneling nanotubes
As a new method of cell-cell communication, tunneling nanotubes (TNTs) play important roles in cell- cell signaling and mass exchanges. However, a lack of powerful tools to visualize dynamic TNTs with high temporal/spatial resolution restricts the exploration of their formation and cleavage, hindering the complete understanding of its mechanism. Herein, we present the first example of using stochastic optical reconstruction microscopy (STORM) to observe the tube-like structures of TNTs linking live cells with an easily prepared fluorescent dye. Because of this new imaging microscopy, the cleavage process of TNTs was observed with a high spatial resolution.
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Wanjun GONG, Wenhui PAN, Ying HE, Meina HUANG, Jianguo ZHANG, Zhenyu GU, Dan ZHANG, Zhigang YANG, Junle QU. Super-resolution imaging of the dynamic cleavage of intercellular tunneling nanotubes[J]. Frontiers of Optoelectronics, 2020, 13(4): -1
Category: RESEARCH ARTICLE
Received: Jul. 18, 2020
Accepted: Sep. 11, 2020
Published Online: May. 14, 2021
The Author Email: YANG Zhigang (zhgyang@szu.edu.cn)