Using titanium slag as the main raw material, the CaO-MgO-Al2O3-SiO2 series glass-ceramics were prepared by the melting method. Through integrated thermal analyzer, X-ray diffractometer, and scanning electron microscopy, the effect of SiO2 content on the stability and crystallization behavior of the base glass of titanium slag glass-ceramics was analyzed. The results show that when the original slag is used to prepare glass-ceramics, the structure of the basic glass is unstable, and perovskite crystals are easy to precipitate. With the increase of SiO2 content, the basic glass tends to be stable, the crystallization temperature increases, and the degree of crystallization after heat treatment becomes higher, the microstructure is denser and therefore the strength is higher. The SiO2 content is adjusted by adding the auxiliary raw material quartz powder. When the SiO2 content is 40% (mass fraction), glass-ceramics with stable glass body, crystal phase only diopside, and bending strength of 82.1 MPa are prepared. The content of titanium slag is more than 80%(mass fraction), which has important economic and social effects.